2. Gene
  3. KREMEN2 - kringle containing transmembrane protein 2 Gene

KREMEN2 - kringle containing transmembrane protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 Kringle 跨膜蛋白 2

种属: Homo sapiens

同用名: KRM2

基因 ID: 79412 | 基因类型: protein coding

关于 KREMEN2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,964,275-2,968,380 (from NCBI)

This gene has 6 transcripts (splice variants), 99 orthologues and 1 paralogue. Biased expression in skin (RPKM 2.2), brain (RPKM 0.7) and 7 other tissues.

功能概要

该基因编码高亲和力的 dickkopf 同系物 1 (DKK1) 跨膜受体。小鼠功能中的一种类似蛋白质与 DKK1 相互作用以阻断无翅 (Wnt) /β-连环蛋白信号传导。编码的蛋白质与 DKK1 和 Wnt 受体脂蛋白受体相关蛋白 6 (LRP6) 形成三元膜复合物，并诱导快速内吞作用并从质膜上去除 LRP6。它包含细胞外 kringle、WSC 和 CUB 结构域。已经观察到该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (Wnt)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the Wnt receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

KREMEN2 基因产物(4)

mRNA Protein Name
NM_001253725.2 NP_001240654.1 kremen protein 2 isoform e precursor
NM_001253726.2 NP_001240655.1 kremen protein 2 isoform f precursor
NM_024507.4 NP_078783.1 kremen protein 2 isoform b precursor
NM_172229.3 NP_757384.1 kremen protein 2 isoform d precursor

KREMEN2 蛋白结构

Kringle

Kringle: Kringle domain (36 - 119)

WSC

WSC: WSC domain (124 - 205)

CUB

CUB: CUB domain (219 - 323)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
蛋白主名 其他名称

kremen protein 2

dickkopf receptor 2

重组 KREMEN2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77976 Kremen-2 Protein, Human (HEK293, His) Q8NCW0 (G26-A364) ≥95%

关联疾病

疾病名称 别名
Sclerosteosis 2

SOST2

Sclerosteosis, Type 2
Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive

Autosomal Recessive Robinow Syndrome

Covesdem Syndrome

RRS1

Costovertebral Segmentation Defect-Mesomelia Syndrome

Rrs

Costovertebral Segmentation Defect With Mesomelia, Formerly

Covesdem Syndrome, Formerly

Costovertebral Segmentation Defect With Mesomelia

Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly

Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly

Robinow, Autosomal Recessive Syndrome, Type 1
Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Fetal Face Syndrome

Robinow Dwarfism

Mesomelic Dwarfism-Small Genitalia Syndrome

Robinow-Silverman-Smith Syndrome

Costovertebral Segmentation Defect With Mesomelia

Covesdem Syndrome

Robinow'S Syndrome

Robinow-Silverman Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07429 KREMEN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus KREMEN2 MGD MGI:1920266
Macaca mulatta KREMEN2 VGNC VGNC:74081
Felis catus KREMEN2 VGNC VGNC:63168
Rattus norvegicus KREMEN2 RGD RGD:1310795
Bos taurus KREMEN2 VGNC VGNC:58604
Canis familiaris KREMEN2 VGNC VGNC:42512
Macaca fascicularis KREMEN2 NCBI
Others KREMEN2 NCBI
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