2. Gene
  3. LPCAT1 - lysophosphatidylcholine acyltransferase 1 Gene

LPCAT1 - lysophosphatidylcholine acyltransferase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶血磷脂酰胆碱酰基转移酶 1

种属: Homo sapiens

同用名: AYTL2; lpcat; AGPAT9; LPLAT8; PFAAP3; AGPAT10; LPCAT-1; lysoPAFAT

基因 ID: 79888 | 基因类型: protein coding

关于 LPCAT1

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:1,461,427-1,523,960 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 249 orthologues and 4 paralogues. Broad expression in lung (RPKM 73.0), spleen (RPKM 32.6) and 18 other tissues.

功能概要

该基因编码 1-acyl-sn-glycerol-3-phosphate 酰基转移酶蛋白家族的成员。编码的酶在磷脂代谢中发挥作用，特别是在存在酰基辅酶 A 的情况下将溶血磷脂酰胆碱转化为磷脂酰胆碱。这个过程在肺表面活性物质和血小板活化因子 (PAF) 的合成中很重要。该基因的表达升高可能有助于口腔鳞状细胞癌、前列腺癌、乳腺癌和其他人类癌症的进展。[RefSeq 提供，2016 年 9 月]

This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate Acyltransferase family of proteins. The encoded Enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016]

LPCAT1 基因产物(1)

mRNA Protein Name
NM_024830.5 NP_079106.3 lysophosphatidylcholine acyltransferase 1

LPCAT1 蛋白结构

Acyltransferase

Acyltransferase: Acyltransferase (115 - 233)

EF-hand_6

EF-hand_6: EF-hand domain (384 - 409)

EF-hand_8

EF-hand_8: EF-hand domain pair (432 - 482)

  • 0
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  • 500
  • 534 a.a.
蛋白主名 其他名称

lysophosphatidylcholine acyltransferase 1

1-acylglycerol-3-phosphate O-acyltransferase

关联疾病

疾病名称 别名
Epithelioid Trophoblastic Tumor

Trophoblastic Tumor, Epithelioid
Newborn Respiratory Distress Syndrome

Hyaline Membrane Disease

Respiratory Distress Syndrome Of Newborn

Neonatal Respiratory Distress

Hmd - Hyaline Membrane Disease

Neonatal Respiratory Distress Syndrome

Pulmonary Hyaline Membrane Disease

Pulmonary Hypoperfusion Syndrome Of Newborn

Respiratory Distress Syndrome, Newborn

Respiratory Distress Syndrome

Cardiorespiratory Distress Syndrome Of Newborn

Distress Respiratory Syndrome Newborn

Idiopathic Respiratory Distress Syndrome

Idiopathic Respiratory Distress Syndrome Of Newborn

Newborn Idiopathic Respiratory Distress Syndrome

Respiratory Distress Syndrome In Newborn

Rds - [Respiratory Distress Syndrome] Of Newborn

Newborn Cardiorespiratory Distress Syndrome
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07764 LPCAT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-112825 TSI-01 / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LPCAT1 RGD RGD:1311599
Mus musculus LPCAT1 MGD MGI:2384812
Macaca mulatta LPCAT1 VGNC VGNC:74361
Felis catus LPCAT1 VGNC VGNC:63264
Bos taurus LPCAT1 VGNC VGNC:30961
Canis familiaris LPCAT1 VGNC VGNC:42748
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