1. Gene
  2. LRRTM4 - leucine rich repeat transmembrane neuronal 4 Gene

LRRTM4 - leucine rich repeat transmembrane neuronal 4 Gene

中文名称:富亮氨酸重复跨膜神经元 4

种属: Homo sapiens

基因 ID: 80059 | 基因类型: protein coding

关于 LRRTM4

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:76,747,685-77,522,376 (from NCBI)

This gene has 7 transcripts (splice variants), 420 orthologues and 22 paralogues. Biased expression in brain (RPKM 5.6) and lung (RPKM 0.2).

功能概要

预测可启用硫酸乙酰肝素蛋白多糖结合活性。预计参与突触组装的调节。预测作用于 AMPA 谷氨酸受体簇的上游或内部;突触组装的正调控;和突触前膜组织的调节。预测位于突触后膜。预计是 AMPA 谷氨酸受体复合物的一部分。预计在细胞外基质中有活性;细胞外空间;和谷氨酸能突触。预计是突触后密度膜的组成部分。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable heparan sulfate proteoglycan binding activity. Predicted to be involved in regulation of synapse assembly. Predicted to act upstream of or within AMPA glutamate receptor clustering; positive regulation of synapse assembly; and regulation of presynaptic membrane organization. Predicted to be located in postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular matrix; extracellular space; and glutamatergic synapse. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRRTM4 基因产物(5)

mRNA Protein Name
NM_001134745.3 NP_001128217.1 leucine-rich repeat transmembrane neuronal protein 4 isoform a precursor
NM_001282924.3 NP_001269853.1 leucine-rich repeat transmembrane neuronal protein 4 isoform a precursor
NM_001282928.3 NP_001269857.1 leucine-rich repeat transmembrane neuronal protein 4 isoform c precursor
NM_001330370.2 NP_001317299.1 leucine-rich repeat transmembrane neuronal protein 4 isoform d precursor
NM_024993.6 NP_079269.4 leucine-rich repeat transmembrane neuronal protein 4 isoform b precursor

LRRTM4 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (66 - 121)

LRR_1

LRR_1: Leucine Rich Repeat (134 - 156)

LRR_8

LRR_8: Leucine rich repeat (159 - 216)

LRR_8

LRR_8: Leucine rich repeat (230 - 289)

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  • 500
  • 590 a.a.
蛋白主名 其他名称

leucine-rich repeat transmembrane neuronal protein 4

重组 LRRTM4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76481 LRRTM4 Protein, Human (HEK293, His) Q86VH4-1 (Q31-K424) ≥95%

关联疾病

疾病名称 别名
Schizophrenia 18

SCZD18

Schizophrenia 18 With Or Without An Affective Disorder

Schizophrenia Susceptibility 18

Chromosome 7q36.3 Duplication Syndrome, 362-Kb

Schizophrenia, Type 18

Epilepsy, Familial Temporal Lobe, 5

Familial Temporal Lobe Epilepsy 5

ETL5

Epilepsy, Temporal Lobe, Familial, Type 5

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LRRTM4 VGNC VGNC:106180
Canis familiaris LRRTM4 VGNC VGNC:42832
Mus musculus LRRTM4 MGD MGI:2389180
Bos taurus LRRTM4 VGNC VGNC:59345
Rattus norvegicus LRRTM4 RGD RGD:1560707
Felis catus LRRTM4 VGNC VGNC:63317
Others LRRTM4 NCBI