ITIH5 - inter-alpha-trypsin inhibitor heavy chain 5 Gene

中文名称：α-胰蛋白酶抑制因子重链 5

种属: Homo sapiens

同用名: ITI-HC5; PP14776

关于 ITIH5

功能概要

该基因编码 inter-alpha-胰蛋白酶抑制剂 (ITI) 家族成员之一的重链成分。 ITI 蛋白参与细胞外基质稳定和预防肿瘤转移。它们也是结构相关的血浆丝氨酸蛋白酶抑制剂，由轻链和不同数量的重链组成。该家族成员被认为在乳腺癌和甲状腺癌中起肿瘤抑制因子的作用。可变剪接导致多个转录本变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine Protease Inhibitors and are composed of a LIGHT chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]