2. Gene
  3. PROK1 - prokineticin 1 Gene

PROK1 - prokineticin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：促动力素 1

种属: Homo sapiens

同用名: PK1; PRK1; EGVEGF

基因 ID: 84432 | 基因类型: protein coding

关于 PROK1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,451,149-110,457,358 (from NCBI)

This gene has 1 transcript (splice variant), 190 orthologues and 1 paralogue. Biased expression in ovary (RPKM 72.8), testis (RPKM 51.2) and 2 other tissues.

功能概要

由该基因编码的蛋白质在源自内分泌腺的毛细血管内皮细胞中诱导增殖、迁移和开窗 (膜不连续的形成) 。它对多种其他内皮细胞和非内皮细胞类型几乎没有影响。它的表达仅限于类固醇生成腺体 (卵巢、睾丸、肾上腺和胎盘) ，由缺氧诱导，并且通常与血管内皮生长因子 (VEGF) 的表达互补，表明这些分子以协调的方式发挥作用。[RefSeq 提供，2011 年 9 月]

The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]

PROK1 基因产物(1)

mRNA Protein Name
NM_032414.3 NP_115790.1 prokineticin-1 precursor

PROK1 蛋白结构

Prokineticin

Prokineticin: Prokineticin (1 - 97)

  • 0
  • 105 a.a.
蛋白主名 其他名称

prokineticin-1

EG-VEGF

重组 PROK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71906 Prokineticin-1/EG-VEGF Protein, Human P58294 (A20-F105) ≥95%
HY-P74616 Prokineticin-1/EG-VEGF Protein, Human (sf9, His) P58294 (M1-F105) ≥95%

关联疾病

疾病名称 别名
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Endocervicitis
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11194 PROK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PROK1 MGD MGI:2180370
Macaca mulatta PROK1 VGNC VGNC:76284
Felis catus PROK1 VGNC VGNC:80324
Rattus norvegicus PROK1 RGD RGD:620898
Canis familiaris PROK1 VGNC VGNC:45010
Bos taurus PROK1 VGNC VGNC:33361
Others PROK1 NCBI
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