2. Gene
  3. CTSF - cathepsin F Gene

CTSF - cathepsin F Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：组织蛋白酶 F

种属: Homo sapiens

同用名: CATSF; CLN13

基因 ID: 8722 | 基因类型: protein coding

关于 CTSF

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,563,464-66,568,606 (from NCBI)

This gene has 39 transcripts (splice variants), 541 orthologues, 12 paralogues and is associated with 2 phenotypes. Broad expression in ovary (RPKM 64.5), testis (RPKM 55.5) and 24 other tissues.

功能概要

组织蛋白酶是木瓜蛋白酶家族的半胱氨酸蛋白酶，代表溶酶体蛋白水解系统的主要成分。组织蛋白酶通常包含信号序列，然后是前肽，然后是催化活性成熟区。组织蛋白酶 F 前体的非常长 (251 个氨基酸残基) 的前区包含一个类似于组织蛋白酶 L 样酶的前区段的 C 末端结构域、一个 50 残基的柔性连接肽和一个 N 末端结构域，预计采用胱抑素样折叠。组织蛋白酶 F 前区在木瓜蛋白酶家族半胱氨酸蛋白酶中是独一无二的，因为它包含这个额外的 N 末端片段，预计与胱抑素超家族的半胱氨酸蛋白酶抑制剂具有结构相似性。这种胱抑素样结构域包含一些已知对抑制活性很重要的元素。 CTSF 编码预测的 484 个氨基酸的蛋白质，其中包含 19 个残基的信号肽。组织蛋白酶 F 包含五个潜在的 N-糖基化位点，它可能通过甘露糖 6-磷酸受体途径靶向内体/溶酶体区室。组织蛋白酶 F 基因普遍表达，它映射到染色体 11q13，靠近编码组织蛋白酶 W 的基因。[RefSeq 提供，2008 年 7 月]

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the Cathepsin F precursor contains a C-terminal domain similar to the pro-segment of Cathepsin L-like Enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The Cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine Protease Inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 Amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The Cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding Cathepsin W. [provided by RefSeq, Jul 2008]

CTSF 基因产物(1)

mRNA Protein Name
NM_003793.4 NP_003784.2 cathepsin F precursor

CTSF 蛋白结构

Inhibitor_I29

Inhibitor_I29: Cathepsin propeptide inhibitor domain (I29) (187 - 244)

Peptidase_C1

Peptidase_C1: Papain family cysteine protease (272 - 481)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 484 a.a.
蛋白主名 其他名称

cathepsin F

重组 CTSF 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71701 CTSF Protein, Human (His) Q9UBX1 (P273-D484) ≥95%

关联疾病

疾病名称 别名
Ceroid Lipofuscinosis, Neuronal, 13

Neuronal Ceroid Lipofuscinosis 13

CLN13

Neuronal Ceroid Lipofuscinosis 13 Kufs Type

Cln13 Disease

Lipofuscinosis, Ceroid, Neuronal, Type 13
Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis

Batten Disease

Ncl

Neuronal Ceroid-Lipofuscinoses

Lipofuscinosis, Ceroid, Neuronal

Juvenile Neuronal Ceroid Lipofuscinosis

Cerebromacular Dystrophy

Cerebromacular Degeneration

Ceroid-Lipofuscinosis

Ncl - [Neuronal Ceroid Lipofuscinosis]

Amaurotic Familial Idiocy

Amaurotic Idiocy

Amaurotic Idiot

Neuronal Lipofuscinosis

Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Ceroid Lipofuscinosis, Neuronal, 10

Neuronal Ceroid Lipofuscinosis Due To Cathepsin D Deficiency

Neuronal Ceroid Lipofuscinosis 10

CLN10

Cathepsin D Deficiency

Congenital Neuronal Ceroid Lipofuscinosis

Neuronal Ceroid Lipofuscinosis Cathepsin D-Deficient

Cln10 Disease

Ceroid Lipofuscinosis, Neuronal, Cathepsin D-Deficient

Cln10 Disease, Adult

Cln10 Disease, Congenital

Cln10 Disease, Juvenile

Cln10 Disease, Late Infantile

Ceroid Lipofuscinosis Neuronal Cathepsin D-Deficient

Cathepsin D Deficient Neuronal Ceroid Lipofuscinosis

Congenital Ncl

Lipofuscinosis, Ceroid, Neuronal, Type 10

Neuronal Ceroid Lipofuscinosis, Congenital
Ceroid Lipofuscinosis, Neuronal, 11

Neuronal Ceroid Lipofuscinosis 11

CLN11

Cln11 Disease

Grn-Related Neuronal Ceroid-Lipofuscinosis

Lipofuscinosis, Ceroid, Neuronal, Type 11
Spinocerebellar Ataxia, Autosomal Recessive 7

SCAR7

Autosomal Recessive Spinocerebellar Ataxia 7

Spinocerebellar Ataxia Autosomal Recessive 7

Childhood Onset Autosomal Recessive Slowly Progressive Spinocerebellar Ataxia

Childhood-Onset Autosomal Recessive Slowly Progressive Spinocerebellar Ataxia

Autosomal Recessive Spinocerebellar Ataxia Type 7

Spinocerebellar Ataxia, Autosomal Recessive, 7

Ataxia, Spinocerebellar, Autosomal Recessive, Type 7
Clonorchiasis

Oriental Liver Fluke Disease

Clonorchis Liver Infection

Clonorchiosis

Chinese Liver Fluke Disease

Hepatic Distomiasis Due To Clonorchis Sinensis

Infection Due To Clonorchis Sinensis

Hepatic Distomiasis

Hepatic Distomatosis

Chinese Liver Fluke Disorder

Oriental Liver Fluke Disorder

Clonorchis Infestation

Chinese Liver Fluke Infestation

Liver Fluke Disease Due To Clonorchis Sinensis

Oriental Liver Fluke Infestation
Progressive Myoclonus Epilepsy 3

Cln14 Disease

Epm3

Neuronal Ceroid Lipofuscinosis 14

Pme Type 3

Progressive Myoclonic Epilepsy Due To Kctd7 Deficiency

Progressive Myoclonus Epilepsy Type 3

Epilepsy, Progressive Myoclonic 3
Keratopathy
Paragonimiasis

Infection By Paragonimus

Lung Fluke Disease

Lung Fluke Infection

Pulmonary Paragonimiasis

Paragonimus Westermani Infection

Pulmonary Distomiasis

Parasitic Haemoptysis

Oriental Lung Fluke Disease

Endemic Haemoptysis

Paragonimosis

Pulmonary Distomatosis

Lung Fluke Disorder

Infestation By Paragonimus

Infection Due To Paragonimus Species

Infestation Due To Paragonimus Species

Oriental Lung Fluke Infestation

Endemic Oriental Haemoptysis
Ceroid Lipofuscinosis, Neuronal, 3

Batten Disease

Juvenile Neuronal Ceroid Lipofuscinosis

Neuronal Ceroid Lipofuscinosis 3

CLN3

Jncl

Spielmeyer-Vogt Disease

Vogt-Spielmeyer Disease

Spielmeyer-Sjogren Disease

Cln3 Disease

Neuronal Ceroid Lipofuscinosis, Juvenile

Cln3 Disease, Juvenile

Spielmeyer Sjogren Disease

Vogt Spielmeyer Disease

Batten-Mayou Disease

Batten-Spielmeyer-Vogt Disease

Cln3-Related Neuronal Ceroid-Lipofuscinosis

Juvenile Batten Disease

Juvenile Cerebroretinal Degeneration

Classic Juvenile Ncl

Classic Juvenile Neuronal Ceroid Lipofuscinosis

Juvenile Ncl

Lipofuscinosis, Ceroid, Neuronal, Type 3
Opisthorchiasis

Infection By Opisthorchis

Infection Due To Opisthorchis

Infection Due To Cat Liver Fluke

Infection By Cat Liver Fluke

Opisthorchiosis

Cat Liver Fluke Fever

Cat Liver Fluke Disease

Opisthorchis Infestation

Cat Liver Fluke Infestation
Spastic Paraplegia 48, Autosomal Recessive

SPG48

Hereditary Spastic Paraplegia 48

Autosomal Recessive Spastic Paraplegia Type 48

Autosomal Recessive Spastic Paraplegia 48

Paraplegia, Spastic, Type 48, Autosomal Recessive
Galactosialidosis

Goldberg Syndrome

Neuraminidase Deficiency With Beta-Galactosidase Deficiency

Ppca Deficiency

GSL

Lysosomal Protective Protein Deficiency

Cathepsin A Deficiency

Neuraminidase/Beta-Galactosidase Expression

Protective Protein/Cathepsin A Deficiency

Ngbe

Cathepsin A Deficiency Of

Lysosomal Protective Protein Deficiency Of

Deficiency Of Cathepsin A

Neuraminidase Beta-Galactosidase Deficiency

Protective Protein Cathepsin A Deficiency
Progressive Myoclonus Epilepsy

Pme

Progressive Myoclonic Epilepsy

Myoclonic Epilepsies, Progressive

Unverricht-Lundborg Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03334 CTSF Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CTSF MGD MGI:1861434
Bos taurus CTSF VGNC VGNC:27815
Macaca mulatta CTSF VGNC VGNC:71555
Rattus norvegicus CTSF RGD RGD:1308181
Canis familiaris CTSF VGNC VGNC:39711
Felis catus CTSF VGNC VGNC:82005
Others CTSF NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z