2. Gene
  3. NRP2 - neuropilin 2 Gene

NRP2 - neuropilin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经毡蛋白 2

种属: Homo sapiens

同用名: NP2; NPN2; PRO2714; VEGF165R2

基因 ID: 8828 | 基因类型: protein coding

关于 NRP2

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:205,682,501-205,798,131 (from NCBI)

This gene has 17 transcripts (splice variants), 285 orthologues and 35 paralogues. Broad expression in placenta (RPKM 10.6), ovary (RPKM 9.8) and 20 other tissues.

功能概要

该基因编码受体蛋白神经毡蛋白家族的一个成员。编码的跨膜蛋白结合 SEMA3C 蛋白 {sema 结构域，免疫球蛋白结构域 (Ig) ，短基本结构域，分泌的， (semaphorin) 3C} 和 SEMA3F 蛋白 {sema 结构域，免疫球蛋白结构域 (Ig) ，短基本结构域，分泌的， (semaphorin) ) 3F}，并与血管内皮生长因子 (VEGF) 相互作用。这种蛋白质可能在心血管发育、轴突导向和肿瘤发生中发挥作用。这种蛋白质还被确定为 SARS-CoV-2 (导致 COVID-19) 感染宿主细胞的共同受体。[RefSeq 提供，2021 年 7 月]

This gene encodes a member of the neuropilin family of Receptor Proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Jul 2021]

NRP2 基因产物(6)

mRNA Protein Name
NM_003872.3 NP_003863.2 neuropilin-2 isoform 2 precursor
NM_018534.4 NP_061004.3 neuropilin-2 isoform 4 precursor
NM_201264.2 NP_957716.1 neuropilin-2 isoform 6 precursor
NM_201266.2 NP_957718.1 neuropilin-2 isoform 1 precursor
NM_201267.2 NP_957719.1 neuropilin-2 isoform 5 precursor
NM_201279.2 NP_958436.1 neuropilin-2 isoform 3 precursor

NRP2 蛋白结构

CUB

CUB: CUB domain (28 - 139)

CUB

CUB: CUB domain (149 - 264)

F5_F8_type_C

F5_F8_type_C: F5/8 type C domain (292 - 424)

F5_F8_type_C

F5_F8_type_C: F5/8 type C domain (449 - 589)

MAM

MAM: MAM domain, meprin/A5/mu (646 - 800)

DUF3481

DUF3481: C-terminal domain of neuropilin glycoprotein (861 - 928)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 931 a.a.
蛋白主名 其他名称

neuropilin-2

neuropilin-2a(17)

NRP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
NRP2 O60462 Vegfc Mus musculus P97953-1
Solid Phase Assay
25752543
种属间
NRP2 O60462 Vegfc Mus musculus P97953-1
TSA
25752543
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NRP2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73313 Neuropilin-2 Protein, Human (HEK293, Fc) O60462 (Q23-Y855) ≥95%
HY-P73314 Neuropilin-2 Protein, Human (855a.a, HEK293, His) O60462 (Q23-P859) ≥95%

关联疾病

疾病名称 别名
Lymphangioma

Lymphatic Malformation

Lymphatic Malformations

Benign Lymphangioma

Congenital Lymphangioma

Lymphangiomas
Wallerian Degeneration

Wallerian Degeneration Of The Pyramidal Tract
Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Hereditary Lymphedema

Milroy Disease
Hereditary Lymphedema I

Lymphedema

Hereditary Lymphedema Type I

Congenital Primary Lymphedema

Lmph1

Milroy Disease

Nonne-Milroy Lymphedema

Pcl

Lymphedema Hereditary Type 1
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09580 NRP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990782 Efzofitimod / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NRP2 RGD RGD:621442
Bos taurus NRP2 VGNC VGNC:32267
Mus musculus NRP2 MGD MGI:1100492
Canis familiaris NRP2 VGNC VGNC:43975
Macaca mulatta NRP2 VGNC VGNC:75533
Felis catus NRP2 VGNC VGNC:68570
Others NRP2 NCBI
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