2. Gene
  3. KYNU - kynureninase Gene

KYNU - kynureninase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：犬尿氨酸酶

种属: Homo sapiens

同用名: KYNUU; VCRL2

基因 ID: 8942 | 基因类型: protein coding

关于 KYNU

Cytogenetic location: 2q22.2 Genomic coordinates (GRCh38): 2:142,877,664-143,055,833 (from NCBI)

This gene has 9 transcripts (splice variants), 224 orthologues and is associated with 4 phenotypes. Broad expression in liver (RPKM 2.5), urinary bladder (RPKM 1.8) and 14 other tissues.

功能概要

Kynureninase 是一种 pyridoxal-5'-phosphate (pyridoxal-P) 依赖性酶，可催化 L-kynurenine 和 L-3-hydroxykynurenine 分别裂解成邻氨基苯甲酸和 3-羟基邻氨基苯甲酸。犬尿氨酸酶通过犬尿氨酸途径参与来自色氨酸的 NAD 辅助因子的生物合成。可变剪接导致多个转录本变体。[RefSeq 提供，2010 年 11 月]

Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent Enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

KYNU 基因产物(3)

mRNA Protein Name
NM_001032998.2 NP_001028170.1 kynureninase isoform b
NM_001199241.2 NP_001186170.1 kynureninase isoform a
NM_003937.3 NP_003928.1 kynureninase isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kynureninase activity IDA
IDA: 通过直接分析推断
9180257 GOA
enables kynureninase activity IMP
IMP: 通过突变表型推断
17334708 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
11985583 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in NAD biosynthetic process IMP
IMP: 通过突变表型推断
28792876 GOA
involved in anthranilate metabolic process IDA
IDA: 通过直接分析推断
11985583 GOA
involved in quinolinate biosynthetic process IDA
IDA: 通过直接分析推断
9291104 GOA
involved in response to type II interferon IDA
IDA: 通过直接分析推断
9291104 GOA
involved in response to vitamin B6 IMP
IMP: 通过突变表型推断
1939450 GOA
involved in tryptophan catabolic process IMP
IMP: 通过突变表型推断
17334708 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
6468727 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
6468727 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KYNU 蛋白结构

Aminotran_5

Aminotran_5: Aminotransferase class-V (119 - 387)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 465 a.a.
蛋白主名 其他名称

kynureninase

重组 KYNU 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75903 KYNU/Kynureninase Protein, Human (sf9, His) Q16719 (M1-N465) ≥95%

关联疾病

疾病名称 别名
Hydroxykynureninuria

Xanthurenic Aciduria

Kynureninase Deficiency

Kynureninase Deficiency, Partial

HYXKY

Partial Kynureninase Deficiency
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 2

VCRL2

Congenital Nad Deficiency Disorder 2

Kynureninase Deficiency, Complete
Congenital Vertebral-Cardiac-Renal Anomalies Syndrome

Congenital Nad Deficiency Disorder
Catel-Manzke Syndrome

Hyperphalangy-Clinodactyly Of Index Finger With Pierre Robin Syndrome

Micrognathia Digital Syndrome

Pierre Robin Syndrome With Hyperphalangy And Clinodactyly

Index Finger Anomaly With Pierre Robin Syndrome

Palatodigital Syndrome, Catel-Manzke Type

Catel Manzke Syndrome

CATMANS

Palatodigital Syndrome Catel-Manzke Type

Index Finger Anomaly-Pierre Robin Syndrome

Pierre Robin Sequence-Hyperphalangy-Clinodactyly Syndrome

Pierre Robin Syndrome-Hyperphalangy-Clinodactyly Syndrome
Transient Cerebral Ischemia

Transient Ischemic Attack

Transient Ischemic Attacks

Tia

Tia - Transient Ischaemic Attack

Transient Cerebral Ischaemia

Ischemic Attack, Transient

Intermittent Cerebral Ischemia

Tia - [Transient Ischaemic Attack]

Intermittent Cerebral Ischaemia

Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified
Pellagra

Niacin Deficiency

Niacin-Tryptophan Deficiency

Pellagroid Syndrome
Meier-Gorlin Syndrome 2

MGORS2

Meier-Gorlin Syndrome, Type 2
Epilepsy, Idiopathic Generalized 9

Epilepsy, Idiopathic Generalized, Susceptibility To, 9

EIG9

Epilepsy, Juvenile Myoclonic 6

Idiopathic Generalized Epilepsy 9

Epilepsy, Juvenile Myoclonic, Susceptibility To, 6

Susceptibility To Idiopathic Generalized Epilepsy 9

Juvenile Myoclonic Epilepsy 6

EJM6

Susceptibility To Juvenile Myoclonic Epilepsy 6

Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 9
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07480 KYNU Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus KYNU VGNC VGNC:30759
Felis catus KYNU VGNC VGNC:67998
Mus musculus KYNU MGD MGI:1918039
Rattus norvegicus KYNU RGD RGD:71061
Canis familiaris KYNU VGNC VGNC:42555
Macaca mulatta KYNU VGNC VGNC:74223
Others KYNU NCBI
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