2. Gene
  3. MICAL2 - microtubule associated monooxygenase, calponin and LIM domain containing 2 Gene

MICAL2 - microtubule associated monooxygenase, calponin and LIM domain containing 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含微管相关的单加氧酶、钙调蛋白和 LIM 结构域 2

种属: Homo sapiens

同用名: MICAL-2; MICALCL; Ebitein1; mical-cL; MICAL2PV1; MICAL2PV2

基因 ID: 9645 | 基因类型: protein coding

关于 MICAL2

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:12,110,590-12,362,140 (from NCBI)

This gene has 37 transcripts (splice variants), 292 orthologues and 36 paralogues. Broad expression in testis (RPKM 23.1), colon (RPKM 17.9) and 24 other tissues.

功能概要

该基因编码的蛋白质是一种单加氧酶，可增强 F-肌动蛋白的解聚，因此参与细胞骨架动力学。编码的蛋白质是 SRF 信号通路的调节剂。该基因表达增加与癌症进展和转移有关。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with Cancer progression and metastasis. [provided by RefSeq, Oct 2016]

MICAL2 基因产物(16)

mRNA Protein Name
NM_001282663.2 NP_001269592.1 [F-actin]-monooxygenase MICAL2 isoform a
NM_001282664.1 NP_001269593.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001282665.1 NP_001269594.1 [F-actin]-monooxygenase MICAL2 isoform c
NM_001282666.1 NP_001269595.1 [F-actin]-monooxygenase MICAL2 isoform d
NM_001282667.1 NP_001269596.1 [F-actin]-monooxygenase MICAL2 isoform e
NM_001282668.2 NP_001269597.1 [F-actin]-monooxygenase MICAL2 isoform f
NM_001346292.2 NP_001333221.1 [F-actin]-monooxygenase MICAL2 isoform a
NM_001346293.2 NP_001333222.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001346294.2 NP_001333223.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001346295.2 NP_001333224.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001346296.2 NP_001333225.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001346297.2 NP_001333226.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001346298.2 NP_001333227.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001346299.2 NP_001333228.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001393937.1 NP_001380866.1 [F-actin]-monooxygenase MICAL2 isoform g
NM_014632.4 NP_055447.1 [F-actin]-monooxygenase MICAL2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin binding IDA
IDA: 通过直接分析推断
24440334 GOA
enables monooxygenase activity IDA
IDA: 通过直接分析推断
29343822 GOA
enables oxidoreductase activity IDA
IDA: 通过直接分析推断
24440334 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament depolymerization IDA
IDA: 通过直接分析推断
24440334 GOA
involved in cytoskeleton organization IDA
IDA: 通过直接分析推断
24440334 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24440334 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in actin filament IDA
IDA: 通过直接分析推断
29343822 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24440334 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MICAL2 蛋白结构

FAD_binding_3

FAD_binding_3: FAD binding domain (87 - 124)

CH

CH: Calponin homology (CH) domain (521 - 621)

LIM

LIM: LIM domain (1002 - 1058)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1124 a.a.
蛋白主名 其他名称

[F-actin]-monooxygenase MICAL2

ERK2-binding testicular protein 1

重组 MICAL2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71756 MICAL2 Protein, Human (P.pastoris, His) O94851 (1M-495H) ≥95%

关联疾病

疾病名称 别名
Trimethylaminuria

TMAU

Fish-Odor Syndrome

Fish Malodor Syndrome

Fish Odor Syndrome

Stale Fish Syndrome

Tmauria

Severe Primary Trimethylaminuria

Mesh

D008661

Fish Odour Syndrome
Griscelli Syndrome

Chediak-Higashi-Like Syndrome

Griscelli-Prunieras Syndrome

Partial Albinism-Immunodeficiency Syndrome

Griscelli Disease

Gs

Hypopigmentation Immunodeficiency Disease

Partial Albinism With Immunodeficiency

Immunodeficiency Syndrome With Hypopigmentation

Hypopigmentation-Immunodeficiency Disease
Mitral Valve Insufficiency

Mitral Regurgitation

Congenital Insufficiency Of Mitral Valve

Congenital Mitral Insufficiency

Congenital Mitral Regurgitation

Mitral Valve Incompetence

Mitral Valve Regurgitation

Mr - [Mitral Regurgitation]

Mi - [Mitral Incompetence]

Mitral Valve Annular Incompetency

Congenital Mitral Valve Incompetence

Congenital Mitral Valve Insufficiency

Congenital Mitral Valve Regurgitation

Congenital Mitral Incompetence
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-145119S Mindeudesivir 99.02% Phase 1
Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P0107A RC-3095 TFA Antagonist 98.12% 否
HY-103316A Ned 19 Inhibitor 99.92% 否
HY-12736A GSK143 dihydrochloride Inhibitor 99.73% 否
HY-109506S DPPC-d62 ≥99.0% 否
HY-109506S1 DPPC-d9 ≥95.0% 否
HY-131102 Mequindox Inhibitor 99.67% 否
HY-W654264 2-Methylbutyrylcarnitine chloride Activator 98.92% 否
HY-P0107 RC-3095 Antagonist / 否
HY-101139 Xanthine amine congener Antagonist / 否
HY-109506S2 (Rac)-DPPC-d6 / 否
HY-109506S3 DPPC-d9-1 ≥99.0% 否
HY-109506S9 DPPC-13C2 ≥95.0% 否
HY-12736 GSK143 Inhibitor / 否
HY-162720 NNRT-IN-4 Inhibitor / 否
HY-B0448S1 Phenytoin-15n2,13c / 否
HY-D0195S Acesulfame-d4 potassium / 否
HY-N1428S3 Citric acid-13C3 / 否
HY-RS08426 MICAL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MICAL2 VGNC VGNC:103135
Macaca mulatta MICAL2 VGNC VGNC:101352
Bos taurus MICAL2 VGNC VGNC:31458
Rattus norvegicus MICAL2 RGD RGD:1311773
Canis familiaris MICAL2 VGNC VGNC:106605
Mus musculus MICAL2 MGD MGI:2444947
Others MICAL2 NCBI
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