2. Gene
  3. USP34 - ubiquitin specific peptidase 34 Gene

USP34 - ubiquitin specific peptidase 34 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素特异性肽酶 34

种属: Homo sapiens

基因 ID: 9736 | 基因类型: protein coding

关于 USP34

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:61,187,463-61,471,087 (from NCBI)

This gene has 22 transcripts (splice variants), 186 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 17.6), lymph node (RPKM 17.0) and 25 other tissues.

功能概要

启用半胱氨酸型内肽酶活性和硫醇依赖性去泛素化酶。参与经典 Wnt 信号通路和蛋白 K48 连接的去泛素化的正调控。预计在胞质溶胶和细胞核中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Enables cysteine-type endopeptidase activity and thiol-dependent Deubiquitinase. Involved in positive regulation of canonical Wnt signaling pathway and protein K48-linked deubiquitination. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP34 基因产物(1)

mRNA Protein Name
NM_014709.4 NP_055524.3 ubiquitin carboxyl-terminal hydrolase 34
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
14715245 GOA
enables cysteine-type endopeptidase activity IMP
IMP: 通过突变表型推断
21383061 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21383061 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
21383061 GOA
involved in protein K48-linked deubiquitination IDA
IDA: 通过直接分析推断
21383061 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

USP34 蛋白结构

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (1894 - 2236)

  • 0
  • 600
  • 1200
  • 1800
  • 2400
  • 3000
  • 3546 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 34

deubiquitinating enzyme 34

关联疾病

疾病名称 别名
Chromosome 2p16.1-P15 Deletion Syndrome

2p15p16.1 Microdeletion Syndrome

2p15-P16.1 Microdeletion Syndrome

Del(2)(P15p16.1)

Monosomy 2p15p16.1

Monosomy 2p15-P16.1
Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome

ARCS1

Arthrogryposis Renal Dysfunction Cholestasis Syndrome

Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

Arcs

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, And Cholestasis

Arthrogryposis-Renal Dysfunction-Cholestasis

Arthrogryposis - Renal Dysfunction - Cholestasis

Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1

Arthrogryposis Renal Dysfunction And Cholestasis 1

Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1

Kidney Failure

Renal Insufficiency
Meningocele

Isolated Spina Bifida

Spina Bifida

Cleft Spine

Open Spine

Rachischisis

Spinal Dysraphism

Spinal Meningocele

Congenital Meningocele
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15545 USP34 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus USP34 RGD RGD:1565181
Felis catus USP34 VGNC VGNC:66880
Mus musculus USP34 MGD MGI:109473
Macaca mulatta USP34 VGNC VGNC:79223
Canis familiaris USP34 VGNC VGNC:48190
Bos taurus USP34 VGNC VGNC:36724
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