1. Gene
  2. Prmt6 - protein arginine N-methyltransferase 6 Gene

Prmt6 - protein arginine N-methyltransferase 6 Gene

中文名称:蛋白质精氨酸 N-甲基转移酶 6

种属: Mus musculus

同用名: Hrmt1l6

基因 ID: 99890 | 基因类型: protein coding

关于 Prmt6

Chromosome 3: 110,153,425-110,158,314 reverse strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 166 orthologues, 7 paralogues and is associated with 11 phenotypes. Ubiquitous expression in ovary adult (RPKM 8.9), adrenal adult (RPKM 6.9) and 28 other tissues.

功能概要

该基因编码的蛋白可启动染色质结合活性和组蛋白-精氨酸 N-甲基转移酶活性。参与肽基-精氨酸 N-甲基化。作用于多个过程的上游或内部,包括细胞衰老;组蛋白 H3-R2 甲基化;氮化合物代谢过程的负调控。预测位于核仁和核质中。表达于中枢神经系统和感觉器官。与人类 PRMT6(蛋白质精氨酸甲基转移酶 6)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables chromatin binding activity and histone-arginine N-methyltransferase activity. Involved in peptidyl-arginine N-methylation. Acts upstream of or within several processes, including cellular senescence; histone H3-R2 methylation; and negative regulation of nitrogen compound metabolic process. Predicted to be located in nucleolus and nucleoplasm. Is expressed in central nervous system and sensory organ. Orthologous to human PRMT6 (protein arginine methyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]

Prmt6 基因产物(1)

mRNA Protein Name
NM_178891.5 NP_849222.3 protein arginine N-methyltransferase 6
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
22904064 MGI
enables histone H3R2 methyltransferase activity IMP
IMP: 通过突变表型推断
22904064 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
26070566 MGI
enables protein-arginine N-methyltransferase activity IDA
IDA: 通过直接分析推断
18495660 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Prmt6 蛋白结构

AdoMet_MTases

AdoMet_MTases: cd02440 (87 - 187)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
蛋白主名 其他名称

protein arginine N-methyltransferase 6

HMT1 hnRNP methyltransferase-like 6

histone-arginine N-methyltransferase PRMT6

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prmt6 NCBI NCBI:55170