1. Anti-infection Cell Cycle/DNA Damage
  2. Antibiotic Bacterial Topoisomerase
  3. Gepotidacin mesylate hydrate

Gepotidacin mesylate hydrate 是一种口服有效的三氮杂苊烯抗生素和细菌 II 型拓扑异构酶抑制剂。Gepotidacin mesylate hydrate 通过阻断拓扑异构酶来抑制细菌 DNA 复制。Gepotidacin mesylate hydrate 选择性抑制拓扑异构酶 IV 和 DNA 旋转酶的 B 亚基。

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Gepotidacin mesylate hydrate Chemical Structure

Gepotidacin mesylate hydrate Chemical Structure

CAS No. : 1624306-20-2

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Gepotidacin mesylate hydrate 的其他形式现货产品:

Other Forms of Gepotidacin mesylate hydrate:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gepotidacin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. Gepotidacin mesylate hydrate inhibits bacterial DNA replication by blocking topoisomerase enzymes. Gepotidacin mesylate hydrate selectively inhibits topoisomerase IV and the B subunit of DNA gyrase[1][2].

体外研究
(In Vitro)

Gepotidacin 是促旋酶催化的 DNA 超螺旋 (IC50 ≈ 0.047 μM) 和正超螺旋底物松弛 (IC50 ≈ 0.6 μM) 的强效抑制剂[1]
Gepotidacin 对 Mueller-Hinton 肉汤中 E. coli 分离株的 MIC 范围为 1 至 4 mg/L[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

580.65

Formula

C25H36N6O8S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Gepotidacin mesylate hydrate
目录号:
HY-16742B
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