2. Apoptosis
  3. Apoptosis Ferroptosis
  4. GIC-20

GIC-20 是细胞凋亡 (apoptosis) 和铁死亡 (ferroptosis) 的双重诱导剂。GIC-20 对纤维肉瘤具有抗肿瘤活性。

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GIC-20 Chemical Structure

GIC-20 Chemical Structure

CAS No. : 2942242-60-4

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GIC-20 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GIC-20 is a dual inducer for apoptosis and ferroptosis. GIC-20 exhibits antitumor efficacy against fibrosarcoma[1].

体外研究
(In Vitro)

GIC-20 (1 μM, 48 h) 抑制 HT1080 纤维肉瘤细胞的增殖和迁移，表现出细胞毒性，IC50 为 1.6 μM[1]。
GIC-20 (0.5-4 μM, 24 h) 通过诱导细胞内脂质过氧化物和 ROS 积累，或通过降解 GPX4 诱导铁死亡 (ferroptosis)[1]。
GIC-20 (0-1 μM, 24 h) 抑制耐药 MIA-PaCa-2-AMG510R 细胞的细胞活力，增强 MIA-PaCa-2-AMG510R 细胞对 AMG510 的敏感性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GIC-20 相关抗体:

Western Blot Analysis[1]

Cell Line: HT1080
Concentration: 0-4 μM
Incubation Time: 24 h
Result: Inhibited expression of GPX4 and Bcl-2, promoted expression of Bax.

Apoptosis Analysis[1]

Cell Line: HT1080
Concentration: 0-4 μM
Incubation Time: 24 h
Result: Induced apoptosis in a dose-dependent manner.
体内研究
(In Vivo)

GIC-20 (20-40 mg/kg，腹腔注射，每天一次共 19 天) 在 HT1080 异种移植 BALB/c 小鼠中表现出抗肿瘤活性，且对主要器官没有明显毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HT1080 xenograft BALB/c mice[1]
Dosage: 20-40 mg/kg
Administration: i.p., once a day for 19 days
Result: Inhibited tumor growth, with a TGI of 63% at 40 mg/kg.
Maintained a complete morphology without obvious cellular inflammatory, oedema, or necrosis in major organs.
分子量

697.24

Formula

C38H37ClN4O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GIC-20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GIC-202942242-60-4GIC20GIC 20ApoptosisFerroptosisHT1080fibrosarcoma MIA-PaCa-2-AMG510RInhibitorinhibitorinhibit

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产品名称：
GIC-20
目录号：
HY-162449
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