2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. GID4 Ligand 1

GID4 Ligand 1 (化合物 88) 是一种细胞渗透性的和高选择性的 GID4 结合剂 (IC50=5.4 μM; Kd=5.6 μM)，能在细胞中与 GID4结合 (EC50=558 nM)。GID4 Ligand 1 可用于合成 PROTACs。

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GID4 Ligand 1 Chemical Structure

GID4 Ligand 1 Chemical Structure

CAS No. : 3031442-96-0

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GID4 Ligand 1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GID4 Ligand 1 (compound 88) is a cell-permeable and high-selective GID4 binder (IC50=5.4 μM; Kd=5.6 μM), binds to GID4 in cells (EC50=558 nM). GID4 Ligand 1 can be used for the synthesis of PROTACs[1].

IC50 & Target

IC50: 5.4 μM (GID4)[1].
体外研究
(In Vitro)

GID4 Ligand 1 (50 μM; 1 h) shows the ability to engage endogenous GID4 protein in HEK293 cells with considerable selectivity[1].
GID4 Ligand 1 (50 μM; 10 min) binds GID4 in lysates of HEK293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GID4 Ligand 1 相关抗体:

Western Blot Analysis[1]

Cell Line: HEK293 cells (expressing FLAG-GID4)
Concentration: 50 μM
Incubation Time: 1 h
Result: Exhibited the ability to permeate the cell membrane and engage FLAG-GID4 in living cells.

Western Blot Analysis[1]

Cell Line: HEK293 cells (expressing FLAG-GID4)
Concentration: 50 μM
Incubation Time: 10 min
Result: Produced a Tm shift of 5.4°C.
分子量

538.66

Formula

C28H34N4O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GID4 Ligand 1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

GID4 Ligand 13031442-96-0Ligands for Target Protein for PROTACTarget Protein-binding MoietyHEK293GID4PROTACInhibitorinhibitorinhibit

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产品名称：
GID4 Ligand 1
目录号：
HY-151475
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