2. Apoptosis PI3K/Akt/mTOR Epigenetics NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Apoptosis AMPK Reactive Oxygen Species
  4. GL-V9

GL-V9 通过诱导细胞凋亡 (apoptosis) 和在 G2/M 期阻滞细胞周期，抑制 HepG2 细胞的增殖 (IC50 为 35.2 μM)。GL-V9 调节线粒体膜电位并增加细胞内活性氧的产生。GL-V9 通过激活 AMPK 抑制戊糖磷酸途径 (PPP)，增强脂肪酸氧化 (FAO)，从而抑制癌细胞的转移。GL-V9 在小鼠模型中表现出抗肿瘤作用。

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GL-V9 Chemical Structure

GL-V9 Chemical Structure

CAS No. : 1178583-19-1

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GL-V9 相关抗体

Top Publications Citing Use of Products

查看 AMPK 亚型特异性产品:

查看所有亚型
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GL-V9 inhibits proliferation of HepG2 cell (IC50 is 35.2 μM) through induction of apoptosis and cell cycle arrest at G2/M phase. GL-V9 regulates mitochondrial membrane potential and increases the production of intracellular reactive oxygen species. GL-V9 inhibits the pentose phosphate pathway (PPP), enhances fatty acid oxidation (FAO) through activation of AMPK, and thus inhibits the metastasis of cancer cells. GL-V9 exhibits antitumor efficacy in mouse model[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
1.53 μM
Compound: 3c
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28117202]
HepG2 IC50
3.61 μM
Compound: 3c
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28117202]
分子量

409.47

Formula

C24H27NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GL-V9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GL-V91178583-19-1ApoptosisAMPKReactive Oxygen SpeciesAMP-activated protein kinaseHepG2ICR mouseH22MDA-MB-231Hepatocellular carcinomaTNBCInhibitorinhibitorinhibit

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目录号：
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