2. GPCR/G Protein
  3. GCGR
  4. Glepaglutide

Glepaglutide  (Synonyms: ZP1848)

目录号: HY-P2221
产品使用指南

摩尔计算器

Glepaglutide (ZP1848)，一种长效的 GLP-2 类似物，是一种有效的 GLP-2R 激动剂。Glepaglutide 可减少粪便排出量并增加肠道吸收。Glepaglutide 可减轻小肠炎症。Glepaglutide 可用于炎症性肠病 (IBD) 和克罗恩病的研究。

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Glepaglutide Chemical Structure

Glepaglutide Chemical Structure

CAS No. : 914009-86-2

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规格 是否有货
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Glepaglutide 的其他形式现货产品:

Customer Review

Other Forms of Glepaglutide:

Glepaglutide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glepaglutide (ZP1848), a long-acting GLP-2 analogue, is a potent GLP-2R agonist. Glepaglutide reduces faecal output and increases intestinal absorption. Glepaglutide alleviates small intestinal inflammation. Glepaglutide can be used in the research of inflammatory bowel disease (IBD) and Crohn’s disease[1][2][3].

IC50 & Target

GLP-2R[3]
体内研究
(In Vivo)

Glepaglutide (200 and 400 nmol/kg, s.c., twice a day for 14 days) shows intestinotrophic effect in rats with small intestinal inflammation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats with Indomethacin (HY-14397)-induced small intestinal inflammation[3]
Dosage: 200 and 400 nmol/kg
Administration: Subcutaneousinjection (s.c.), twice a day for 14 days.
Result: Increased plasma citrulline concentration.
Increased small intestinal mass.
Decreased small intestinal concentrations of the inflammatory marker (AGP and MPO).
Clinical Trial
分子量

4316.08

Formula

C197H325N53O55
CAS 号
Sequence

His-Gly-Glu-Gly-Thr-Phe-Ser-Ser-Glu-Leu-Ala-Thr-Ile-Leu-Asp-Ala-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Ala-Trp-Leu-Ile-Ala-Thr-Lys-Ile-Thr-Asp-Lys-Lys-Lys-Lys-Lys-Lys-NH2
Sequence Shortening

HGEGTFSSELATILDALAARDFIAWLIATKITDKKKKKK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Glepaglutide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glepaglutide914009-86-2ZP1848ZP 1848ZP-1848GCGRGlucagon ReceptorShort bowel syndromeGLP-2long-actingIBDintestinal inflammationInhibitorinhibitorinhibit

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