2. Apoptosis Stem Cell/Wnt
  3. Apoptosis Hedgehog Gli
  4. GLI1-IN-1

GLI1-IN-1 (CBC-1) 是 GLI-1 抑制剂，具有良好的水溶性和抗癌活性。GLI1-IN-1 可以诱导细胞凋亡 (apoptosis)，并且通过抑制Hedgehog (HH) (IC50=1.3 μM) 通路来抑制结直肠癌的生长。

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GLI1-IN-1 Chemical Structure

GLI1-IN-1 Chemical Structure

CAS No. : 2923907-92-8

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GLI1-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GLI1-IN-1 (CBC-1) is a GLI-1 inhibitor with excellent water solubility and anticancer activity. GLI1-IN-1 can induce apoptosis and suppress the growth of colorectal cancer by inhibiting the Hedgehog(HH) (IC50=1.3 μM) pathway[1].

IC50 & Target

IC50: 1.3 μM (Hedgehog)[1].
体外研究
(In Vitro)

GLI1-IN-1 (CBC-1) (5-40 μM; 24-48 h) 具有抗癌活性，在 HT-29, SW-480 和 HCT-116 细胞中通过抑制 HH 通路的 mRNA 和蛋白表达来抑制细胞增殖，IC50 值分别为 7.13、15.31、3.33 μM。GLI1-IN-1 (5-40 μM; 24 h) 可以诱导 HT-29 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GLI1-IN-1 相关抗体:

Apoptosis Analysis[1]

Cell Line: HT-29
Concentration: 5, 10, 20, 40 µM;
Incubation Time: 24 h
Result: Increased the number of apoptotic cells in a concentration-dependent manner.

RT-PCR[1]

Cell Line: HT-29
Concentration: 5, 10, 20, 40 µM;
Incubation Time: 24 h, 48 h
Result: Decreased the mRNA expression of SHH, SMO, GLI1, and PTCH in a concentration- and time-dependent manner.
Significantly reduced the mRNA expression levels of the apoptosis-related factor BCL-2 and increased the levels of the apoptosis-promoting factor BAX in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: HT-29
Concentration: 5, 10, 20, 40 µM;
Incubation Time: 24 h
Result: Decreased the protein expression of SHH, SMO and GLI1 in a concentration-dependent manner.
体内研究
(In Vivo)

GLI1-IN-1 (CBC-1) (50 mg/kg; 腹腔注射; 一天一次连续 16 天) 在 BALB/c/nu/nu 裸鼠中可以有效抑制异种移植物模型中的肿瘤生长， 肿瘤抑制率为 68%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tumour xenograft BALB/c/nu/nu nude mice model[1].
Dosage: 50 mg/kg
Administration: Intraperitoneal injection (i.p.); Once daily for 16 days
Result: Significantly reduced the size and weight of HT29 tumor xenografts.
Decreased the protein expression of GLI -1.
分子量

736.93

Formula

C42H60N2O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GLI1-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLI1-IN-12923907-92-8ApoptosisHedgehogGliColorectal cancer (CRC)HT-29SW-480HCT-116apoptosisInhibitorinhibitorinhibit

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