2. Metabolic Enzyme/Protease
  3. Glutaminase
  4. GLS1 Inhibitor-3

GLS1 Inhibitor-3 (compound C147) 是一种有效的 GLS1 抑制剂，IC50 为 27.98 nM。GLS1 Inhibitor-3 具有抗增殖活性。

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GLS1 Inhibitor-3 Chemical Structure

GLS1 Inhibitor-3 Chemical Structure

CAS No. : 2435781-94-3

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GLS1 Inhibitor-3 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GLS1 Inhibitor-3 (compound C147) is a potent GLS1 inhibitor with an IC50 of 27.98 nM. GLS1 Inhibitor-3 shows antiproliferative activity[1].

IC50 & Target

IC50: 27.98 nM (GLS1)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
0.15 μM
Compound: C147
Antiproliferative activity against human HCT-116 cells overexpressing GLS1 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells overexpressing GLS1 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 35428013]
HCT-116 IC50
0.15 μM
Compound: C147
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31603674]
MDA-MB-436 IC50
0.18 μM
Compound: C147
Antiproliferative activity against human MDA-MB-436 cells overexpressing GLS1 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-436 cells overexpressing GLS1 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 35428013]
MDA-MB-436 IC50
0.18 μM
Compound: C147
Antiproliferative activity against human MDA-MB-436 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-436 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31603674]
分子量

596.71

Formula

C30H32N10O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GLS1 Inhibitor-3 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLS1 Inhibitor-32435781-94-3GlutaminaseHCT116MDA-MB-436 cellsmetabolic stabilityantiproliferativeInhibitorinhibitorinhibit

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目录号：
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