2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. Glucocorticoid receptor modulator 3

Glucocorticoid receptor modulator 3 

目录号: HY-163672
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摩尔计算器

Glucocorticoid receptor modulator 3 (Payload 6) 是一种含硫酯的糖皮质激素受体 (glucocorticoid receptor) 调节剂 (IC50=0.6 nM)。Glucocorticoid receptor modulator 3 通过快速的肝脏代谢来灭活非偶联形式的有效载荷，从而最小化系统性暴露。Glucocorticoid receptor modulator 3 可用于针对自身免疫疾病的抗体偶联活性分子 (ADCs) 的开发。

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Glucocorticoid receptor modulator 3 Chemical Structure

Glucocorticoid receptor modulator 3 Chemical Structure

CAS No. : 2688785-13-7

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Glucocorticoid receptor modulator 3 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

Glucocorticoid receptor modulator 3 (Payload 6) is a thioester-containing glucocorticoid receptor modulator (IC50=0.6 nM). Glucocorticoid receptor modulator 3 is designed to inactivate unconjugated payloads rapidly through liver metabolism, thereby minimizing systemic exposure. Glucocorticoid receptor modulator 3 can be utilized in the development of antibody-drug conjugates (ADCs) targeting autoimmune diseases[1].

分子量

563.63

Formula

C29H32F3NO5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Glucocorticoid receptor modulator 3 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucocorticoid receptor modulator 32688785-13-7Glucocorticoid receptor modulator3Glucocorticoid receptor modulator-3Glucocorticoid ReceptorGlucocorticoidsLiver MetabolismAutoimmune diseasesADCInhibitorinhibitorinhibit

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