2. Anti-infection
  3. Bacterial
  4. Glutamate-5-kinase-IN-2

Glutamate-5-kinase-IN-2 (compound 54) 是一种有效的 glutamate-5-kinase (G5K) 抑制剂，MIC (最小抑制浓度)为 4.2 μM. Glutamate-5-kinase-IN-2 通过促进 L-谷氨酸结合位点的构象变化来抑制 G5K 活性。Glutamate-5-kinase-IN-2 具有抗结核活性分子研究的潜力。

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Glutamate-5-kinase-IN-2 Chemical Structure

Glutamate-5-kinase-IN-2 Chemical Structure

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Glutamate-5-kinase-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glutamate-5-kinase-IN-2 (compound 54) is a potent glutamate-5-kinase (G5K) inhibitor with an MIC (minimum inhibitory concentration) of 4.2 µM. Glutamate-5-kinase-IN-2 shows G5K inhibition by promotes conformational changes at the L-glutamate binding site. Glutamate-5-kinase-IN-2 has the potential for the research of anti-TB agents[1].

IC50 & Target

G5K[1]
体外研究
(In Vitro)

Glutamate-5-kinase-IN-2 (compound 54) (40 µM) inhibits G5K activity with an I0.5 of 33 µM at 10 mM concentration of L-Glu and ATP[1].
Glutamate-5-kinase-IN-2 (5, 10, 20 µM) shows no relevant cytotoxicity in HepG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Glutamate-5-kinase-IN-2 相关抗体:
分子量

296.73

Formula

C17H10ClFN2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Glutamate-5-kinase-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glutamate-5-kinase-IN-2Bacterialanti-TBHepG2 cellsL-glutamateATPInhibitorinhibitorinhibit

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