Goniothalamin (Synonyms: GTN; (R)-(+)-Goniothalamin)

目录号: HY-N3968 纯度: ≥98.0%: FAQs
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Goniothalamin (GTN) 是一种具有抗肿瘤、抗炎、免疫抑制等特性的苯乙烯内酯。Goniothalamin 诱导多种癌细胞系的细胞毒性，DNA 损伤和凋亡。

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Goniothalamin Chemical Structure

CAS No. : 17303-67-2

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生物活性
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参考文献

生物活性

Goniothalamin (GTN) is styryllactone with anticancer, anti-inflammatory, immunosuppressive properties. Goniothalamin induces cytotoxicity, DNA damage and apoptosis of a variety of cancer cell lines^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	5.7 μM Compound: (R)-1	Antiproliferative activity against human A549 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human A549 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 28214230]
DU-145	IC₅₀	19 μM Compound: 1a	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 19022676]
HaCaT	IC₅₀	28.6 μM Compound: 1	Cytotoxicity against human HaCaT cells assessed as reduction in cell viability after 24 hrs by MTT reduction assay Cytotoxicity against human HaCaT cells assessed as reduction in cell viability after 24 hrs by MTT reduction assay	[PMID: 25305718]
HBL-100	IC₅₀	20.9 μM Compound: (R)-1	Antiproliferative activity against human HBL100 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human HBL100 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 28214230]
HepG2	IC₅₀	0.625 μM Compound: 1	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 to 72 hrs Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 to 72 hrs	[PMID: 31306909]
HepG2	IC₅₀	1.6 μM Compound: 1	Cytotoxicity against human HepG2 cells after 24 hrs Cytotoxicity against human HepG2 cells after 24 hrs	[PMID: 20392543]
K562	IC₅₀	7 μM Compound: Goniothalamin	Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay	[PMID: 24775915]
LNCaP	IC₅₀	12 μM Compound: 1a	Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 19022676]
MCF7	IC₅₀	28 μM Compound: 1a	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 19022676]
MCF7	IC₅₀	4.5 μM Compound: 1	Cytotoxicity against human MCF7 cells after 24 hrs Cytotoxicity against human MCF7 cells after 24 hrs	[PMID: 20392543]
MCF7	IC₅₀	55.5 μM Compound: (R)-1	Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 28214230]
PANC-1	IC₅₀	65 μM Compound: 1	Antiproliferative activity against human PANC1 cells assessed as reduction in colonies after 15 days by colony assay Antiproliferative activity against human PANC1 cells assessed as reduction in colonies after 15 days by colony assay	[PMID: 25305718]
PANC-1	IC₅₀	65 μM Compound: 1	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 24 hrs by MTT reduction assay Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 24 hrs by MTT reduction assay	[PMID: 25305718]
PC-3	IC₅₀	4 μM Compound: 1a	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 19022676]
RAW264.7	IC₅₀	27.4 μM Compound: 1	Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 18 hrs by luciferase assay Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 18 hrs by luciferase assay	[PMID: 23735825]
RAW264.7	IC₅₀	34.2 μM Compound: 1	Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay	[PMID: 23735825]

Clinical Trial

分子量

200.23

Formula

C₁₃H₁₂O₂

CAS 号

17303-67-2

性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥98.0%

选择批次：

Data Sheet (522 KB) SDS (393 KB)

COA (168 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Seyed MA, et al. Emerging anticancer potentials of goniothalamin and its molecular mechanisms. Biomed Res Int. 2014;2014:536508. [Content Brief]

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Goniothalamin17303-67-2GTN (R)-(+)-GoniothalaminApoptosisanticancerimmunosuppressivecytotoxicityDNA damageapoptosisInhibitorinhibitorinhibit

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营业执照（三证合一）

Goniothalamin (Synonyms: GTN; (R)-(+)-Goniothalamin)

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Goniothalamin (Synonyms: GTN; (R)-(+)-Goniothalamin)

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Goniothalamin 相关产品

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•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

Goniothalamin 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

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