2. Apoptosis Anti-infection Cell Cycle/DNA Damage
  3. Apoptosis HPV DNA/RNA Synthesis
  4. GS-9191

GS-9191 是核苷酸类似物 PMEG 的前药。GS-9191 是一种外用制剂，可渗透皮肤并在上皮层代谢为活性核苷三磷酸类似物。GS-9191 抑制 DNA 合成，使细胞停滞在 S 期，并诱导细胞凋亡(apoptosis)。GS-9191 可用于人乳头瘤病毒 (HPV) 感染的研究。

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GS-9191 Chemical Structure

GS-9191 Chemical Structure

CAS No. : 859209-84-0

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规格 价格 是否有货 数量
1 mg ￥2905
1 - 2 周
5 mg 现货 1 - 2 周
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

GS-9191 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Ca-Ski EC50
2.03 nM
Compound: GS-9191
Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay
Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay
[PMID: 19398642]
HeLa EC50
0.71 nM
Compound: GS-9191
Antiproliferative activity against HPV-transformed human HeLa cells after 7 days by SRB assay
Antiproliferative activity against HPV-transformed human HeLa cells after 7 days by SRB assay
[PMID: 19398642]
HT-3 EC50
5.42 nM
Compound: GS-9191
Antiproliferative activity against HPV-non-transformed human HT3 cells after 7 days by SRB assay
Antiproliferative activity against HPV-non-transformed human HT3 cells after 7 days by SRB assay
[PMID: 19398642]
ME-180 EC50
1.83 nM
Compound: GS-9191
Antiproliferative activity against HPV-transformed human ME180 cells after 7 days by SRB assay
Antiproliferative activity against HPV-transformed human ME180 cells after 7 days by SRB assay
[PMID: 19398642]
SCC-4 EC50
5.03 nM
Compound: GS-9191
Antiproliferative activity against HPV-non-transformed human SCC4 cells after 7 days by SRB assay
Antiproliferative activity against HPV-non-transformed human SCC4 cells after 7 days by SRB assay
[PMID: 19398642]
SCC-9 EC50
15.3 nM
Compound: GS-9191
Antiproliferative activity against HPV-non-transformed human SCC9 cells after 7 days by SRB assay
Antiproliferative activity against HPV-non-transformed human SCC9 cells after 7 days by SRB assay
[PMID: 19398642]
SiHa EC50
> 74 nM
Compound: GS-9191
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 hrs by ELISA
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 hrs by ELISA
[PMID: 19398642]
SiHa EC50
0.03 nM
Compound: GS-9191
Antiproliferative activity against HPV-transformed human SiHa cells after 7 days by SRB assay
Antiproliferative activity against HPV-transformed human SiHa cells after 7 days by SRB assay
[PMID: 19398642]
SiHa EC50
1 nM
Compound: GS-9191
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 6 to 9 hrs by ELISA
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 6 to 9 hrs by ELISA
[PMID: 19398642]
SiHa EC50
1.8 nM
Compound: GS-9191
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 24 to 27 hrs by ELISA
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 24 to 27 hrs by ELISA
[PMID: 19398642]
SiHa EC50
11.5 nM
Compound: GS-9191
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 72 to 75 hrs by ELISA
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 72 to 75 hrs by ELISA
[PMID: 19398642]
SiHa EC50
7.8 nM
Compound: GS-9191
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 to 6 hrs by ELISA
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 to 6 hrs by ELISA
[PMID: 19398642]
SiHa EC50
7.9 nM
Compound: GS-9191
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 48 to 51 hrs by ELISA
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 48 to 51 hrs by ELISA
[PMID: 19398642]
分子量

734.82

Formula

C37H51N8O6P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GS-9191 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS-9191859209-84-0GS9191GS 9191ApoptosisHPVDNA/RNA SynthesisHuman papillomavirusnucleotide analogPMEGDNA synthesisInhibitorinhibitorinhibit

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目录号：
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