2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. H-(Gly)3-Lys(N3)-OH

H-(Gly)3-Lys(N3)-OH 是一种含有叠氮基团的点化学试剂。叠氮化物官能团广泛用于通过著名的点击化学与含炔烃的片段偶联。据报道，含有多达 7 种甘氨酸的聚甘氨酸片段与表面结合，在纳米结构中有潜在的应用：含有多肽的 Gly7-NHCH2 片段在水溶液中与云母表面结合。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。它还可以和含有 DBCO 或 BCN 基团的分子发生环张力促进的炔-叠氮环加成反应 (SPAAC)。

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H-(Gly)3-Lys(N3)-OH Chemical Structure

H-(Gly)3-Lys(N3)-OH Chemical Structure

CAS No. : 2250437-45-5

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H-(Gly)3-Lys(N3)-OH 的其他形式现货产品:

Other Forms of H-(Gly)3-Lys(N3)-OH:

H-(Gly)3-Lys(N3)-OH 相关抗体

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  • 生物活性

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生物活性

The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction. Polyglycine fragments containing up to 7 glycines are reported to bind to surfaces and have potential application in nanotechnology constructs: constructs of Gly7-NHCH2-fragment containing peptides bind on mica surface in aqueous solution[1][2]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

分子量

343.34

Formula

C12H21N7O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

H-(Gly)3-Lys(N3)-OH 相关分类

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Keywords:

H-(Gly)3-Lys(N3)-OH2250437-45-5ADC LinkerAntibody-drug conjugates linkerclick chemistryhigh yieldhigh specificitysimplicitybindingInhibitorinhibitorinhibit

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