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  4. H2-005

H2-005是一种选择性抑制二酰基甘油酰转移酶2（DGAT2）的化合物，具有抑制肝细胞和前脂肪细胞中三酰甘油合成的活性。H2-005在HepG2肝细胞和3T3-L1前脂肪细胞中显著降低三酰甘油的生物合成。H2-005在DGAT2过表达的HEK293细胞中展现出特异性的抑制活性。H2-005几乎完全抑制了在3T3-L1细胞中与DGAT1抑制剂共同处理时的脂滴形成。H2-005将有助于DGAT2相关的脂质代谢研究及代谢疾病抑制的药物开发。

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H2-005 Chemical Structure

H2-005 Chemical Structure

CAS No. : 1060478-12-7

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H2-005 相关抗体

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  • 生物活性

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生物活性

H2-005 is a compound that selectively inhibits diacylglycerol acyltransferase 2 (DGAT2) and has the activity to inhibit triacylglycerol synthesis in hepatocytes and preadipocytes. H2-005 significantly reduces triacylglycerol biosynthesis in HepG2 hepatocytes and 3T3-L1 preadipocytes. H2-005 exhibits specific inhibitory activity in DGAT2-overexpressing HEK293 cells. H2-005 almost completely inhibits lipid droplet formation in 3T3-L1 cells when co-treated with a DGAT1 inhibitor. H2-005 will contribute to DGAT2-related lipid metabolism research and the development of drugs to inhibit metabolic diseases[1].

分子量

440.54

Formula

C24H32N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

H2-005 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

H2-0051060478-12-7OthersInhibitorinhibitorinhibit

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