2. Anti-infection
  3. HCV
  4. HCV-IN-37

HCV-IN-37 (Compound 3d) 是一种有效的 HCV 抑制剂。以 15 mg/kg 的单剂量对大鼠口服给药后，HCV-IN-37 可口服并在大鼠血浆中持久存在。活性衍生物 HCV-IN-37 的高效力主要是由对病毒进入阶段的抑制作用驱动的。

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HCV-IN-37 Chemical Structure

HCV-IN-37 Chemical Structure

CAS No. : 2425804-98-2

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HCV-IN-37 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HCV-IN-37 (Compound 3d) is a potent inhibitor of HCV. HCV-IN-37 is orally available and long-lasting in rat plasma after oral administration to rats by a single dose of 15 mg/kg. The high potency of active derivative HCV-IN-37 is primarily driven by the inhibitory effect on the virus entry stage[1].

IC50 & Target

EC50: 0.005 ± 0.005 μM (HCV)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Huh-7.5 CC50
3.31 μM
Compound: 3d
Cytotoxicity against human Huh7.5 cells infected with HCVcc assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human Huh7.5 cells infected with HCVcc assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 35050619]
Huh-7.5 CC50
3.95 μM
Compound: 3d
Cytotoxicity against human Huh7.5 cells carrying HCV subgenomic replicons assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human Huh7.5 cells carrying HCV subgenomic replicons assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 35050619]
Huh-7.5 CC50
6.24 μM
Compound: 3d
Cytotoxicity against human Huh7.5 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human Huh7.5 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 35050619]
分子量

515.64

Formula

C31H35F2N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HCV-IN-37 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HCV-IN-372425804-98-2HCVHepatitis C virusorally availablevirus entry stageInhibitorinhibitorinhibit

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目录号：
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