2. Cell Cycle/DNA Damage Epigenetics Protein Tyrosine Kinase/RTK
  3. HDAC VEGFR
  4. HDAC-IN-35

HDAC-IN-35 (Compound 14) 是一个有效的、选择性的 HDAC 和 VEGFR-2 抑制剂，对 HDAC6 和 VEGFR-2 的 IC50 值分别为0.166和13.2 µM。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

HDAC-IN-35 Chemical Structure

HDAC-IN-35 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

HDAC-IN-35 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-35 (Compound 14) is a potent, selective HDAC and VEGFR-2 inhibitor, with IC50 values of 0.166 and 13.2 µM for HDAC6 and VEGFR-2, respectively[1].

IC50 & Target

HDAC6

0.166 μM (IC50)

HDAC8

1.99 μM (IC50)

HDAC1

7.23 μM (IC50)

VEGFR2

13.2 μM (IC50)

体外研究
(In Vitro)

HDAC-IN-35 (Compound 14) (0-10 µM, 48 h) shows anticancer effects in different cancer cells[1].
HDAC-IN-35 (0-10 µM, 48 h) exhibits potent anti-angiogenic activity with a GI>50 (50% growth inhibition) value of 1.0 μM on human endothelial progenitor cells (EPCs) through a VEGFR-2-dependent pathway, without obvious systemic toxicity[1].
HDAC-IN-35 exhibits moderate VEGFR-2 inhibitory activities and displays the anticancer effects by inhibiting the enzymatic activity of HDAC[1].
HDAC-IN-35 (0-10 µM, 24 h) concentration-dependently impedes the capillary-like tube formation in human EPCs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-35 相关抗体:

Cell Viability Assay[1]

Cell Line: A549, PC-3, and SK-Hep-1
Concentration: 0-10 µM
Incubation Time: 48 h
Result: Showed anticancer effects with IC50 values of 3.4, 1.9 and 3.2 µM against A549, PC-3, and SK-Hep-1 cells.

Western Blot Analysis[1]

Cell Line: A549, PC-3, and SK-Hep-1, and human EPCs
Concentration: 0, 5, and 10 µM
Incubation Time: 24 h
Result: Increased the amount of acetylated α-tubulin and histone H3 in a concentration-dependent manner in cancer cells. Induced mild inhibition of the phosphorylation of VEGFR-2 in human EPCs.
分子量

399.75

Formula

C17H13ClF3N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-35 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-35HDACVEGFRHistone deacetylasesVascular endothelial growth factor receptorA549PC-3SK-Hep-1EPCsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
HDAC-IN-35
目录号：
HY-146539
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z