Hexa-D-arginine TFA  (Synonyms: Furin Inhibitor II TFA)

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo^[1][2][3].

Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)^[3]

Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1068.17

C₃₈H₇₆F₃N₂₅O₈

958204-56-3

Arg-Arg-Arg-Arg-Arg-Arg-NH2

RRRRRR-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9.  [Content Brief]

  [2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5.  [Content Brief]

  [3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9.  [Content Brief]