2. Others
  3. Drug Derivative
  4. HHQ16

HHQ16 是黄芪甲苷 IV (HY-N0431) 的口服活性衍生物。HHQ16 通过靶向降解 lnc4012/lnc9456、拮抗其对 G3BP2/NF-κB 信号传导的影响，来有效逆转梗塞引起的肥大和心力衰。

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HHQ16 Chemical Structure

HHQ16 Chemical Structure

CAS No. : 2620471-66-9

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HHQ16 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HHQ16 is an orally active derivative of Astragaloside IV (HY-N0431). HHQ16 effectively reverses infarction-induced hypertrophy and heart failure by targeted degrading lnc4012/lnc9456 and antagonizing their effects on G3BP2/NF-κB signaling[1].

体外研究
(In Vitro)

HHQ16 (100 nM，6 小时) 与 lnc9456 高亲和力结合，并诱导其在 HL-1 小鼠心肌细胞中降解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HHQ16 相关抗体:
体内研究
(In Vivo)

HHQ16 (1-100 mg/kg，口服灌胃，每日一次，持续 4 周) 可有效逆转左冠状动脉前降支结扎 (LADL) 引起的小鼠心功能恶化和结构重塑[1]。
HHQ16 (10 mg/kg，口服，2 周) 可降低 AAV-lnc9456 小鼠心脏中高水平的 lnc9456，并消除与重塑相关的变化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: left anterior descending coronary artery ligation (LADL)-induced heart failure mice[1]
Dosage: 1- 100 mg/kg
Administration: oral gavage, daily for 4 weeks
Result: Increased theeft ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) of the mice.
Reduced the enlarged heart size and the heart weight to body surface area ratio (HW/BSA).
Reversed LADL-induced hypertrophy by decreasing the cell volume (size) and slippage (disorderly aligned myocytes).
Reversed LADL-induced increase in ANP, BNP, β-MHC, and hypertrophic expression of ANP and BNP.
分子量

510.70

Formula

C30H48F2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HHQ16 相关分类

  • 摩尔计算器

  • 稀释计算器

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HHQ162620471-66-9HHQ 16HHQ-16Drug DerivativeDrug derivativeinfarctionhypertrophyheart failurecardiomyocytesInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-160706
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