2. Metabolic Enzyme/Protease
  3. HIV Integrase
  4. HIV-1 integrase inhibitor 12

HIV-1 integrase inhibitor 12 (Compound 17) 是 HIV-1 整合酶 (HIV-1 integrase) 的抑制剂，IC50 为 1.4 nM。HIV-1 integrase inhibitor 12 抑制 HIV-1 WT 和 HIV-1 T125A，IC50 分别为 7.4 和 120 nM。HIV-1 integrase inhibitor 12 在大鼠中表现出代谢稳定性和 Caco-2 通透性以及良好的药代动力学特性，具有良好的生物利用度 (64%) 和低清除率 (0.16 L/hr/kg)。

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HIV-1 integrase inhibitor 12 Chemical Structure

HIV-1 integrase inhibitor 12 Chemical Structure

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HIV-1 integrase inhibitor 12 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

HIV-1 integrase inhibitor 12 (Compound 17) is an inhibitor for HIV-1 integrase with an IC50 of 1.4 nM. HIV-1 integrase inhibitor 12 inhibits the HIV-1 WT and HIV-1 T125A, with IC50 of 7.4 and 120 nM, respectively. HIV-1 integrase inhibitor 12 exhibits metabolic stability and Caco-2 permeability, and good pharmacokinetic characteristics with good bioavailability (64%) and low clearance (0.16 L/hr/kg) in rats[1].

分子量

469.66

Formula

C29H43NO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HIV-1 integrase inhibitor 12 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 integrase inhibitor 12HIV IntegraseMT-4HIV-1 NL4-3 WTInhibitorinhibitorinhibit

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