2. Anti-infection Metabolic Enzyme/Protease
  3. HIV Protease
  4. HIV-1 protease-IN-2

HIV-1 protease-IN-2 是一种有效的 HIV-1 protease 抑制剂，其IC50 为 2.53 nM。HIV-1 protease-IN-2 对 DRV (达芦那韦)敏感或耐药性 HIV-1 突变体均显示出抗病毒活性。

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HIV-1 protease-IN-2 Chemical Structure

HIV-1 protease-IN-2 Chemical Structure

CAS No. : 2248124-46-9

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HIV-1 protease-IN-2 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC50 of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants[1].

IC50 & Target

IC50: 2.53 nM (HIV-1 protease)[1]
体外研究
(In Vitro)

HIV-1 protease-IN-2 (compound 10e) (100 nM) shows a promising inhibition ratio of 68% at 100 nM for wild-type HIV-1[1].
HIV-1 protease-IN-2 (0-1000 nM) shows antiviral activity against DRV (Darunavir)-sensitive or resistant pseudotyped HIV-1 with EC50s of 0.27 µM and 0.59 µM for HIV-1NL4-3 and HIVRDRVS, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HIV-1 protease-IN-2 相关抗体:
分子量

558.65

Formula

C27H34N4O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HIV-1 protease-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 protease-IN-22248124-46-9HIV ProteaseAntiviralDarunavirlow cytotoxicityDRV-resistant HIV-1 variantsInhibitorinhibitorinhibit

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