2. JAK/STAT Signaling Apoptosis Stem Cell/Wnt
  3. STAT Apoptosis
  4. HJC0152 free base

HJC0152 (free base) 是一种有口服活性的，有效的 STAT3 抑制剂。HJC0152 (free base) 抑制细胞周期进程，诱导细胞凋亡 (apoptosis)。HJC0152 (free base) 显著抑制小鼠体内的 MDA-MB-231 异种移植瘤的生长。

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HJC0152 free base Chemical Structure

HJC0152 free base Chemical Structure

CAS No. : 1420290-88-5

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HJC0152 free base 的其他形式现货产品:

Other Forms of HJC0152 free base:

HJC0152 free base 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HJC0152 (free base) is an orally active and potent inhibitor of STAT3. HJC0152 (free base) inhibits cell cycle progression and induces apoptosis. HJC0152 (free base) significantly suppresses MDA-MB-231 xenograft tumor growth in mice[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
ASPC1 IC50
1.9 μM
Compound: 11, HJC0152
Cytotoxicity against human AsPC1 cells after 72 hrs by MTS assay
Cytotoxicity against human AsPC1 cells after 72 hrs by MTS assay
[PMID: 23459613]
MCF-10A IC50
6.73 μM
Compound: 2; HJC0152
Cytotoxicity against human MCF-10A cells incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells incubated for 72 hrs by MTT assay
[PMID: 35334447]
MCF7 IC50
0.91 μM
Compound: 11, HJC0152
Cytotoxicity against human ER positive MCF7 cells after 72 hrs by MTS assay
Cytotoxicity against human ER positive MCF7 cells after 72 hrs by MTS assay
[PMID: 23459613]
MCF7 IC50
4.14 μM
Compound: 2; HJC0152
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 35334447]
MDA-MB-231 IC50
1.64 μM
Compound: 11, HJC0152
Cytotoxicity against human ER negative MDA-MB-231 cells after 72 hrs by MTS assay
Cytotoxicity against human ER negative MDA-MB-231 cells after 72 hrs by MTS assay
[PMID: 23459613]
MDA-MB-231 IC50
3.48 μM
Compound: 2; HJC0152
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 35334447]
MDA-MB-468 IC50
5.05 μM
Compound: 2; HJC0152
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 35334447]
PANC-1 IC50
1.08 μM
Compound: 11, HJC0152
Cytotoxicity against human PANC1 cells after 72 hrs by MTS assay
Cytotoxicity against human PANC1 cells after 72 hrs by MTS assay
[PMID: 23459613]
T47D IC50
1.88 μM
Compound: 2; HJC0152
Antiproliferative activity against human T47D cells assessed as inhibition of cell growth incubated fro 72 hrs by MTT assay
Antiproliferative activity against human T47D cells assessed as inhibition of cell growth incubated fro 72 hrs by MTT assay
[PMID: 35334447]
分子量

370.19

Formula

C15H13Cl2N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HJC0152 free base 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HJC01521420290-88-5HJC 0152HJC-0152STATApoptosisSTAT3Niclosamide derivativesMDA-MB-231 xenograftInhibitorinhibitorinhibit

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