2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Stem Cell/Wnt
  3. HSP Hedgehog
  4. HSP70-IN-3

HSP70-IN-3 是一种有效的热休克蛋白 (HSP70) 抑制剂 (ASZ001 和 C3H10T1/2 的 IC50 分别为1.1和1.9 μM)。HSP70-IN-3 具有抗 Hedgehog 信号转导通路活性和抗增殖活性，并降低致癌转录因子 GLI1 的表达。

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HSP70-IN-3 Chemical Structure

HSP70-IN-3 Chemical Structure

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HSP70-IN-3 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HSP70-IN-3 is a potent HSP70 inhibitor (IC50s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1[1].

IC50 & Target

IC50: 1.1 μM (HSP70) in ASZ001, 1.9 μM (HSP70) in C3H10T1/2[1]
体外研究
(In Vitro)

HSP70-IN-3 (compound 8) (5 μM; 72 hours) has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity in ASZ001 cells[1].
HSP70-IN-3 can almost completely abolish the expression of Gli1 mRNA in ASZ001 cells after 20-hour incubation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HSP70-IN-3 相关抗体:

Cell Proliferation Assay

Cell Line: ASZ001 cells[1]
Concentration: 5 μM
Incubation Time: 72 hours
Result: Showed anti-Hh(Hedgehog signaling) activity and anti-proliferative activity.

Cell Proliferation Assay

Cell Line: ASZ001 cells[1]
Concentration: 10 μM
Incubation Time: 48 hours
Result: After a 20-h incubation with HSP70-IN-3, expression of Gli1 mRNA was almost completely abolished.
分子量

883.23

Formula

C48H78N6O7S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HSP70-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP70-IN-3HSPHedgehogHeat shock proteinsVitamin D3Affinity-based proteinHeat shock protein 70Hedgehog pathwayBasal cell carcinomaInhibitorinhibitorinhibit

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目录号：
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