2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Hsp90-IN-15

Hsp90-IN-15 是一种 Hsp90 抑制剂，显示出抗癌活性。Hsp90-IN-15 诱导细胞凋亡 (apoptosis)，阻滞 S 期细胞周期，并降低 Hela 细胞中 Hsp90 的表达水平。

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Hsp90-IN-15 Chemical Structure

Hsp90-IN-15 Chemical Structure

CAS No. : 2252283-32-0

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Hsp90-IN-15 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hsp90-IN-15 is an Hsp90 inhibitor with anticancer activity. Hsp90-IN-15 induces cell apoptosis, arrests the cell cycle at S phase and decreases the expression level of Hsp90 in Hela cell[1].

IC50 & Target

HSP90

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
19.6 μM
Compound: 22g
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31928863]
HepG2 IC50
16.1 μM
Compound: 22g
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31928863]
MDA-MB-231 IC50
22.1 μM
Compound: 22g
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31928863]
体外研究
(In Vitro)

Hsp90-IN-15 (compound 22g) againsts HeLa, HepG2, and MDA-MB-23 cells with IC50s of 19.6 μM, 16.1 μM, and 22.1 μM, respectively[1].
Hsp90-IN-15 binds with Hsp90N, and the △Tm value is 10.92 °C[1].
Hsp90-IN-15 (0-20 μM; 48 h) arrests cell cycle at S phase in a dose-dependent manner[1].
Hsp90-IN-15 (0-20 μM; 48 h) exhibits an accumulation of early and late apoptotic cells in a time and dose dependent manner[1].
Caspase-3 is an executioner caspase and modifies apoptosis proteins[1].
Hsp90-IN-15 (0-50 μM; 48 h) increases the expression of Bax and cleaved-caspase 3, as well as downregulates the levels of Bcl-2, pro-caspase 3 and Hsp90[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hsp90-IN-15 相关抗体:

Cell Viability Assay[1]

Cell Line: HeLa cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: 48 hours
Result: Arrested cell cycle at S phase dose-dependently.

Apoptosis Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: 48 hours
Result: Induced apoptosis in HeLa cells.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 12.5, 25, 50 μM
Incubation Time: 48 hours
Result: Decreased the level of Hsp90 and increased the proportion of Bax/Bcl-2 as well.
分子量

416.48

Formula

C23H27F3N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hsp90-IN-15 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hsp90-IN-152252283-32-0HSPHeat shock proteinsL-shaped matrine derivativesanticancer activitytargeted modificationMDA-MB-231HepG2HeLaInhibitorinhibitorinhibit

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