2. NF-κB
  3. NF-κB
  4. HSR1304

HSR1304 (Compound 5d) 是一种有效的 NFκB 抑制剂。多功能转录因子核因子-κB (NF-κB) 广泛参与多种人类疾病，例如癌症和慢性炎症。HSR1304 具有研究癌症疾病的潜力。

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HSR1304 Chemical Structure

HSR1304 Chemical Structure

CAS No. : 2763363-08-0

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HSR1304 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HSR1304 (Compound 5d) is a potent inhibitor of NFκB. The multifunctional transcription factor, nuclear factor-κB (NF-κB), is broadly involved in multiple human diseases, such as cancer and chronic inflammation. HSR1304 has the potential for the research of cancer diseases[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
ACHN GI50
1.977 μM
Compound: 5d
Anticancer activity against human ACNH cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
Anticancer activity against human ACNH cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
[PMID: 34500188]
HCT-15 GI50
1.739 μM
Compound: 5d
Anticancer activity against human HCT-15 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
Anticancer activity against human HCT-15 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
[PMID: 34500188]
MDA-MB-231 GI50
2.281 μM
Compound: 5d
Anticancer activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
Anticancer activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
[PMID: 34500188]
NCI-H23 GI50
1.938 μM
Compound: 5d
Anticancer activity against human NCI-H23 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
Anticancer activity against human NCI-H23 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
[PMID: 34500188]
NUGC-3 GI50
1.591 μM
Compound: 5d
Anticancer activity against human NUCC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
Anticancer activity against human NUCC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
[PMID: 34500188]
PC-3 GI50
2.008 μM
Compound: 5d
Anticancer activity against human PC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
Anticancer activity against human PC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method
[PMID: 34500188]
分子量

420.89

Formula

C24H21ClN2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HSR1304 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSR13042763363-08-0HSR 1304HSR-1304NF-κBNuclear factor-κBNuclear factor-kappaBNFκBcancerchronic inflammationInhibitorinhibitorinhibit

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目录号：
HY-144745
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