Human PTHrP-(1-36) 

Human PTHrP-(1-36) is a secretory form of PTHrP with anticalciuric effects. Human PTHrP-(1-36) enhances beta cell function and proliferation. Human PTHrP-(1-36) can be used in the research of humoral hypercalcemia of malignancy (HHM) and hyperparathyroidism^[1][3].

Human PTHrP-(1-36) (EC₅₀: 0.05 nM) increases intracellular calcium in human epidermal keratinocytes^[2].
Human PTHrP-(1-36) (100 nM, 24 h) increases human β-cell proliferation^[3].
Human PTHrP-(1-36) (100 nM, 30 min) enhances insulin secretion in human islets^[3].
PTHrP-(1-36) (mouse, EC₅₀: 1 nM) induces a rapid Ca²⁺ response in UMR 106 cells^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PTHrP-(1-36) (mouse, 160 μg/kg, s.c., for 5 days/week for 7, 30, or 90 days) enhances beta cell regeneration and increases beta cell mass in a mouse model of partial pancreatectomy^[5].
PTHrP-(1-36) (mouse, 100 μg/kg, s.c., every other day) reverses the observed decrease of Wisp1 expression in the diabetic mice^[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4259.83

C₁₉₁H₃₀₅N₅₉O₅₂

172867-62-8

固体

White to off-white

AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEI

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. Everhart-Caye M, et al. Parathyroid hormone (PTH)-related protein(1-36) is equipotent to PTH(1-34) in humans. J Clin Endocrinol Metab. 1996 Jan;81(1):199-208.  [Content Brief]

  [2]. Orloff JJ, et al. Analysis of PTHRP binding and signal transduction mechanisms in benign and malignant squamous cells. Am J Physiol. 1992 May;262(5 Pt 1):E599-607.  [Content Brief]

  [3]. Guthalu Kondegowda N, et al. Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression. Diabetes. 2010 Dec;59(12):3131-8.  [Content Brief]

  [4]. Valín A, et al. C-terminal parathyroid hormone-related protein (PTHrP) (107-139) stimulates intracellular Ca(2+) through a receptor different from the type 1 PTH/PTHrP receptor in osteoblastic osteosarcoma UMR 106 cells. Endocrinology. 2001 Jul;142(7):2752-9.  [Content Brief]

  [5]. Mozar A, et al. Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy. PLoS One. 2016 Jul 8;11(7):e0158414.

  [6]. Portal-Núñez S, et al. Alterations of the Wnt/beta-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice. FEBS Lett. 2010 Jul 16;584(14):3095-100.  [Content Brief]