2. Metabolic Enzyme/Protease Autophagy Immunology/Inflammation NF-κB Neuronal Signaling
  3. Prolyl Endopeptidase (PREP) Autophagy Reactive Oxygen Species α-synuclein
  4. HUP-55

HUP-55 是一种脯氨酸内肽酶抑制剂 (IC50 = 5 nM)。 HUP-55 能够减少 Neuro2a 细胞中 α-synuclein 的二聚化，并诱导 HEK293 细胞的自噬 (Autophagy)，并在 10 µM 浓度下减少 SH-SY5Y 细胞中由过氧化氢引起的活性氧 (ROS) 产生的增加。在小鼠帕金森病模型中，HUP-55 (10 mg/kg) 能改善小鼠运动能力 (减少受损侧爪的使用频率)，并降低由过度表达 α-synuclein 引起的大脑纹状体中有害寡聚体的水平。

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HUP-55 Chemical Structure

HUP-55 Chemical Structure

CAS No. : 3006795-68-9

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HUP-55 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HUP-55 is a prolyl endopeptidase inhibitor (IC50 = 5 nM). HUP-55 reduces the dimerization of α-synuclein in Neuro2a cells and induces autophagy (Autophagy) in HEK293 cells. It also decreases the increase in reactive oxygen species (ROS) production induced by hydrogen peroxide in SH-SY5Y cells at a concentration of 10 µM. In a mouse Parkinson’s disease model, HUP-55 (10 mg/kg) improves motor function (reduces the use frequency of the impaired paw) and decreases the levels of harmful oligomers of α-synuclein in the striatum caused by overexpression of α-synuclein[1].

分子量

295.38

Formula

C18H21N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HUP-55 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HUP-553006795-68-9HUP55HUP 55Prolyl Endopeptidase (PREP)AutophagyReactive Oxygen Speciesα-synucleinprolyl oligopeptidasePOPα-SynInhibitorinhibitorinhibit

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