2. Membrane Transporter/Ion Channel
  3. URAT1 GLUT
  4. hURAT1 inhibitor 1

hURAT1 inhibitor 1 (compound 27b) 是异苦参碱类的、口服有效的 hURAT1/GLUT9 双重抑制剂，IC50s 分别为 0.16 μM 和 4.47 μM，具有抗高尿酸血症的作用。hURAT1 inhibitor 1 在高尿酸血症小鼠模型中表现出显著降尿酸活性 (10 mg/kg 剂量)。hURAT1 inhibitor 1 无显著体外细胞毒性或体内肝脏毒性，并表现出良好的 PK 特征。

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hURAT1 inhibitor 1 Chemical Structure

hURAT1 inhibitor 1 Chemical Structure

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hURAT1 inhibitor 1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hURAT1 inhibitor 1 (compound 27b) is an isomarine-based, orally active dual hURAT1/GLUT9 inhibitor with IC50s of 0.16 μM and 4.47 μM, respectively, and has anti-hyperuricemia effects. hURAT1 inhibitor 1 showed significant uric acid-lowering activity in a hyperuricemia mouse model (10 mg/kg dose). hURAT1 inhibitor 1 had no significant in vitro cytotoxicity or in vivo hepatotoxicity and showed good PK characteristics[1].

IC50 & Target

IC50: 0.16 μM (hURAT1); 4.47 μM (GLUT9)[1]
分子量

451.31

Formula

C24H19BrO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hURAT1 inhibitor 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hURAT1 inhibitor 1URAT1GLUTUrate transporter 1SLC22A12Glucose transporterInhibitorinhibitorinhibit

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产品名称：
hURAT1 inhibitor 1
目录号：
HY-162829
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