2. Anti-infection
  3. Bacterial
  4. IDD-8E

IDD-8E 是一种有效的抗假单胞菌物质（MIC = 4.4 µM），没有细胞毒性。IDD-8E 显示了明显的假单胞杀伤和假单胞生物膜的破坏。 IDD-8E 与 WaaP 的 ATP 结合袋结合，也能抑制其他 ESKAPE 病原体。

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IDD-8E Chemical Structure

IDD-8E Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

IDD-8E 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDD-8E is an effective anti-pseudomonal agent (MIC =4.4 µM ) with no cytotoxicity. IDD-8E shows significant pseudomonal killing and disruption of pseudomonal biofilm. IDD-8E binds to the ATP-binding pocket of WaaP and also inhibits other ESKAPE pathogens. [1]

体外研究
(In Vitro)

IDD-8E (10-100 µM; 24h) 使用 RAW 细胞，在较高的浓度下，IDD-8E 的细胞存活率与未经治疗的对照相比保持不变，表明没有细胞毒性[1]。
IDD-8E (2, 4.4 µM; 0-8 h) 观察到铜绿假单胞菌数量明显减少,与 Rifampicin (HY-B0272) 一样有效，抑制了假单胞菌生长。并且发现具有破坏生物膜的能力[1]。
IDD-8E 与三种抗生素 (Rifampicin (HY-B0272), Lincomycin (HY-117660), Carbenicillin (HY-B0525)) 的多种组合具有协同作用。协同组合有效地减少了抗生素的最小抑制浓度 (MICs)[1]。
IDD-8E 可以抑制其他细菌病原体的生长。 A. baumannii, K. pneumoniae, Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococcus faecalis (VRE) and E. coli 的 MIC 值分别是 6.25 µM, 50 µM, 12.5 µM, 12.5 µM 和 50 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IDD-8E 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: RAW cells
Concentration: 100 µM, 70 µM, 40 µM, and 10 µM
Incubation Time: 24 h
Result: IDD-8E showed no significant cytotoxic effects at the concentrations tested, similar to the negative control, Rifampicin. This indicates that IDD-8E is potentially safe for further development as it does not harm the macrophage cells at effective antibacterial concentrations.
分子量

404.42

Formula

C21H20N6O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDD-8E 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDD-8EBacterialPseudomonas aeruginosaRifampicinRAW cellbacterial pathogensbiofilmInhibitorinhibitorinhibit

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目录号：
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