2. Metabolic Enzyme/Protease Apoptosis
  3. Isocitrate Dehydrogenase (IDH) Apoptosis
  4. IDH1/2-IN-1

IDH1/2-IN-1 (Compound 6b) 是 IDH1(R132H)/IDH2(R140Q) 的双抑制剂，IC50 值分别为 0.22 μM 和 1.6 μM。IDH1/2-IN-1 通过抑制肿瘤细胞增殖并激活抗氧化酶以增强宿主防御，有效遏制肿瘤生长。同时 IDH1/2-IN-1 能减少炎症并促进凋亡 (apoptosis)，展现出良好的抗肿瘤活性。IDH1/2-IN-1 可以用于白血病的研究。

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IDH1/2-IN-1 Chemical Structure

IDH1/2-IN-1 Chemical Structure

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IDH1/2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Isocitrate Dehydrogenase (IDH) 亚型特异性产品:

查看所有亚型
IDH1 IDH2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDH1/2-IN-1 (Compound 6b) serves as a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. IDH1/2-IN-1 effectively inhibits tumor growth by suppressing tumor cell proliferation and enhancing host defense through the activation of antioxidant enzymes. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating robust antitumor activity. IDH1/2-IN-1 holds potential for research in leukemia[1].

IC50 & Target

IC50: 0.22 μM (IDH1(R132H))[1].
IC50: 1.6 μM (IDH2(R140Q))[1].
体外研究
(In Vitro)

IDH1/2-IN-1 (Compound 6b) 对 THP1 和 Kasumi 白血病癌细胞表现出优异的抗肿瘤活性，其 IC50 值分别为 10.7 μM 和 10 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IDH1/2-IN-1 相关抗体:
分子量

580.62

Formula

C26H28N8O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDH1/2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDH1/2-IN-1Isocitrate Dehydrogenase (IDH)ApoptosisTHP1KasumiLeukemiaapoptosisInhibitorinhibitorinhibit

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