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  4. II399

II399 是一种有效和选择性的 NNMT 双底物抑制剂，包含非常规 SAM 模拟物，Ki 值为 5.9 nM。II399 对 NAM 表现出明显的竞争性抑制模式。II399 可以占据底物和辅因子结合口袋。 II399 有潜力用于癌症、代谢、心血管和神经退行性疾病的研究。

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II399 Chemical Structure

II399 Chemical Structure

CAS No. : 2928480-72-0

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II399 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

II399 is a potent, selective NNMT bisubstrate inhibitor containing an unconventional SAM mimic, with a Ki of 5.9 nM. II399 exhibits an explicit pattern of competitive inhibition for NAM. II399 occupies both the substrate and cofactor binding pockets. II399 has the potential for the research of cancers, metabolic, cardiovascular, and neurodegenerative diseases[1][2].

IC50 & Target

NNMT[1]
分子量

481.93

Formula

C24H24ClN5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

II399 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

II3992928480-72-0II 399II-399OthersNNMTSAMunconventionalNAMInhibitorinhibitorinhibit

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