2. Anti-infection
  3. Bacterial
  4. IITR08367

IITR08367 是一种有效的效应泵 Acinetobacter baumannii Fosfomycin Efflux pump (AbaF) 抑制剂，用于增强 Fosfomycin (HY-B1075A) 对 Acinetobacter baumannii 的抗菌活性。通过干扰 Fosfomycin/H+ 反向转运活动来发挥作用。

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IITR08367 Chemical Structure

IITR08367 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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IITR08367 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IITR08367 is a potent effector pump Acinetobacter baumannii Fosfomycin Efflux pump (AbaF) inhibitor for enhancing the antimicrobial activity of Fosfomycin (HY-B1075A) against Acinetobacter baumannii. IITR08367 acts by interfering with Fosfomycin/H+ reverse transporter activity. [1].

体外研究
(In Vitro)

IITR08367 (0-50 μM) 浓度依赖性的增强了 Fosfomycin 对 AbaF 表达菌株大肠杆菌的活性。在浓度 50 μM时使 Fosfomycin 的 抗生素后效应增加了 30 分钟[1]。
IITR08367 (25 μM; 16 min) 破坏了膜上的 H+ 梯度，最终抑制了 H+ 梯度驱动的外排泵，且不引起膜损伤[1]。
IITR08367 (100 μM; 12 h) 和 Fosfomycin (64 mg/L) 和联合应用可以抑制 A. baumannii RPTC-15 生长[1]。
IITR08367 (100 μM) 可在加入或不加入 Fosfomycin 的情况下消除 A. baumannii 的生物膜形成能力[1]。
IITR08367 (12.5-200 μM) 对红细胞没有任何毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IITR08367 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: RBCs
Concentration: 12.5; 25; 50; 100; 200 μM
Incubation Time: 6 h
Result: Showed less than 40% cytotoxicity till 200 µM
体内研究
(In Vivo)

IITR08367 (i.p.; 30 mg/kg; 每12小时一次，持续54小时) 和 Fosfomycin 联合用药使尿路感染小鼠表现出显著改善了 A. baumannii RPTC-15 造成的损伤，组织超微结构与未感染的小鼠相似[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Urinary tract infections mice[1]
Dosage: 30 mg/kg; every 12 h for 54 h
Administration: i.p.
Result: Reduced the load of A. baumannii RPTC-15 in the kidney and bladder by approximately 3log10.
分子量

274.44

Formula

C16H18S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IITR08367 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IITR08367IITR 08367IITR-08367Bacterialefflux pump inhibitorurinary tract infectionC. elegansbiofilm inhibitionUTI modelInhibitorinhibitorinhibit

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产品名称：
IITR08367
目录号：
HY-163473
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