2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Mitochondrial Metabolism Reactive Oxygen Species
  4. Imeglimin

Imeglimin (EMD 387008) 是一种口服降糖剂。Imeglimin 可改善胰岛素敏感性。Imeglimin 还减少活性氧 (ROS) 的产生，增加了线粒体 DNA，并改善线粒体功能。

该游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式 Imeglimin hydrochloride。

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Imeglimin Chemical Structure

Imeglimin Chemical Structure

CAS No. : 775351-65-0

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规格 价格 是否有货
5 mg ￥980
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10 mg ￥1550
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50 mg ￥4650
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Imeglimin 的其他形式现货产品:

Other Forms of Imeglimin:

Imeglimin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1].

IC50 & Target

ROS; mitochondrial function[1]
体外研究
(In Vitro)

Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) fully prevents tert-butylhydroperoxide (tBH)-induced cell death[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Imeglimin 相关抗体:

Cell Viability Assay[2]

Cell Line: Human endothelial cells (HMEC-1)
Concentration: 100 μM and10 mM
Incubation Time: 100 μM for 24 h, 10 mM for 4 h
Result: Prevention of cell death.
体内研究
(In Vivo)

Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, restores normal glucose tolerance, and improves insulin sensitivity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6JOlaHsd mice (4 weeks old)[1]
Dosage: 200 mg/kg
Administration: Oral gavage; b.i.d.; 6 weeks
Result: A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.
Clinical Trial
分子量

155.20

Formula

C6H13N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Imeglimin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imeglimin775351-65-0EMD 387008EMD387008EMD-387008Mitochondrial MetabolismReactive Oxygen SpeciesoralglucoseloweringinsulinsensitivityROSmitochondrialfunctionInhibitorinhibitorinhibit

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