Indapamide-¹³C,d₃  (Synonyms: 吲达帕胺-¹³C,d₃)

Indapamide-¹³C,d₃ is ¹³C and deuterium labeled Indapamide. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy^[1][4][5].

369.85

C₁₅¹³CH₁₃D₃ClN₃O₃S

2934053-07-1

26807-65-8

吲达帕胺-¹³C,d₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Chaffman, M, et, al. Indapamide. Drugs 28, 189–235 (1984).

  [3]. Furman BL, et, al. A further examination of the possible effects of indapamide on glucose tolerance and insulin secretion in the rat and mouse. J Pharm Pharmacol. 1981 Nov;33(11):735-7.  [Content Brief]

  [4]. Lalande A, et, al. Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. J Bone Miner Res. 2001 Feb;16(2):361-70.  [Content Brief]

  [5]. Ma F, et, al. Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol Pharmacol. 2013 Aug;84(2):286-95.  [Content Brief]