Indapamide hemihydrate  (Synonyms: 吲达帕胺半水合物)

Indapamide hemihydrate is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide hemihydrate is also can reduce left ventricular hypertrophy^[1][4].

Indapamide (0.1-500 mg/L; 20min) reduces total insulin secretory response to glucose infusions in isolated perfused rat pancreas^[2].
Indapamide (1-100 μM) increases osteoblast proliferation and decreased bone resorption^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Indapamide (1 mg/kg/d; gastric gavage for 8 weeks) lowers blood pressure in spontaneously hypertensive rats (SHRs)^[4].
Indapamide (10 mg/kg/d) decreases pressor response to oxotremorine, noradrenaline, and tyramine in rats^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

749.69

C₁₆H₁₆ClN₃O₃S.1/2H₂O

180004-24-4

吲达帕胺半水合物

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chaffman, M, et, al. Indapamide. Drugs 28, 189–235 (1984).

  [2]. Furman BL, et, al. A further examination of the possible effects of indapamide on glucose tolerance and insulin secretion in the rat and mouse. J Pharm Pharmacol. 1981 Nov;33(11):735-7.  [Content Brief]

  [3]. Lalande A, et, al. Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. J Bone Miner Res. 2001 Feb;16(2):361-70.  [Content Brief]

  [4]. Ma F, et, al. Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol Pharmacol. 2013 Aug;84(2):286-95.  [Content Brief]