Indatraline hydrochloride  (Synonyms: 茚达曲林盐酸盐; Lu 19-005)

Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis^[1].

monoamine transporter^[1]

Indataline hydrochloride (0-5 μM;24小时;EGFP-LC3稳定细胞) 使LC3^[1]。
Indataline hydrochloride (1-10 μM;24小时;HeLa细胞) 使EGFP-LC3荧光空泡在细胞质^[1]。
Indataline hydrochloride (1-20 μM) 抑制平滑肌细胞增殖，IC₅₀=15 μM。Indataline 还诱导细胞自噬，影响 AMPK/mTOR/S6K 信号轴^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Indatraline (2 μM) hydrochloride 抑制平滑肌细胞的新生内膜积聚^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

328.66

C₁₆H₁₆Cl₃N

96850-13-4

茚达曲林盐酸盐

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Cho YS, et al. Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway. Sci Rep. 2016; 6:34655.  [Content Brief]