Infliximab  (Synonyms: 英夫利昔单抗; Avakine; CT-P13)

Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research^[1][2].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

TNF-α 处理的脂肪细胞显示胰岛素刺激的葡萄糖摄取显著降低 64%，而 Infliximab (10 ng/mL) 通过显著改善 3T3L1 脂肪细胞中的葡萄糖掺入来逆转 TNF-α 作用。Infliximab 通过减弱蛋白酪氨酸磷酸酶 1B (PTP1B) 激活来恢复底物 2 和 AKT 的磷酸化。Infliximab 通过抑制 PTP1B 恢复胰岛素信号通路，从而在体外改善 3T3L1 脂肪细胞中 TNF-α 诱导的胰岛素抵抗^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

在糖尿病 TNF-α^+/+) 小鼠中单次注射 Infliximab (100 ul 盐水中的 10 μg/g/剂量 ip) 可抑制血清 TNF-α 升高并改善电生理和生化缺陷至少 4 周。Infliximab 也减弱了糖尿病背根神经节中增加的 TNF-α mRNA 表达^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

170277-31-3

固体

White to off-white

英夫利昔单抗

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG1 kappa

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  Loaded Infliximab on AHC2 biosensor, can bind TNF-alpha/TNFSF2 Protein, Human (HEK293, His-Avi, HY-P70527) with an affinity constant of <1.000E-11 M as determined in BLI assay.

• [1]. Lucia A Méndez-García, et al. Infliximab ameliorates tumor necrosis factor-alpha-induced insulin resistance by attenuating PTP1B activation in 3T3L1 adipocytes in vitro. Scand J Immunol. 2018 Nov;88(5):e12716.  [Content Brief]

  [2]. Isamu Yamakawa, et al. Inactivation of TNF-α ameliorates diabetic neuropathy in mice. Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E844-52.  [Content Brief]