2. Metabolic Enzyme/Protease
  3. HIV Integrase
  4. Integrase-LEDGF/p75 allosteric inhibitor 1

Integrase-LEDGF/p75 allosteric inhibitor 1 

目录号: HY-147653
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Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) 是一种具有口服活性的 integrase-LEDGF/p75 (IN-LEDGF/p75) 变构抑制剂。Integrase-LEDGF/p75 allosteric inhibitor 1 抑制 HIV-1 DNA 整合，具有抗病毒活性，对 HIV-1重组分子克隆 NL432 的 EC50 为 3.9 nM。

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Integrase-LEDGF/p75 allosteric inhibitor 1 Chemical Structure

Integrase-LEDGF/p75 allosteric inhibitor 1 Chemical Structure

CAS No. : 1431738-14-5

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Integrase-LEDGF/p75 allosteric inhibitor 1 相关抗体

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生物活性

Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. Integrase-LEDGF/p75 allosteric inhibitor 1 inhibits HIV-1 DNA integration and shows antiviral activity with an EC50 of 3.9 nM against HIV-1 recombinant molecular clone NL432[1].

IC50 & Target

EC50: 3.9 nM (NL432)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MT4 CC50
24000 nM
Compound: 31h
Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 4 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 4 days by MTT assay
[PMID: 32773094]
体内研究
(In Vivo)

Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) has moderate metabolic stability (HLM MS = 59%, RLM MS = 61%), exhibits good clearance (CLt = 6.99 mL/min/kg) and good bioavailability (F = 36%) in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

579.75

Formula

C33H41NO6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Integrase-LEDGF/p75 allosteric inhibitor 1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Integrase-LEDGF/p75 allosteric inhibitor 11431738-14-5HIV IntegraseAIDSHIVgood bioavailabilityMT-4 cellsNL432Inhibitorinhibitorinhibit

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