2. Others
  3. Fluorescent Dye
  4. IR-990

IR-990 是一种可激活的 NIR-II 型荧光探针，具有受体-π-受体 (A-π-A) 骨架，可在体内实时检测 H2O2。IR-990 可对活性分子引起的肝损伤 (DILI) 进行诊断。

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IR-990 Chemical Structure

IR-990 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

IR-990 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IR-990 is an activatable NIR-II fluorescent probe with an acceptor-π-acceptor (A-π-A) skeleton for real-time detection of H2O2 in vivo. IR-990 is a powerful diagnosis of agent-induced liver injury (DILI)[1].

体外研究
(In Vitro)

IR-990 (0-30 μM) treatment shows high cell viability[1].
IR-990 (10 μM; 1 h) can sensitively visualize endogenous H2O2 levels in cells, and possess excellent ability to detect H2O2 in the cell model of acetaminophen-induced liver injury[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IR-990 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HeLa and HepG2 cells
Concentration: 0-30 μM
Incubation Time:
Result: Observed high cell viability after the cells treated with different concentrations of IR-990.

Cell Viability Assay[1]

Cell Line: HeLa cells
Concentration: 10 μM
Incubation Time: 1 hour
Result: Observed NIR-II fluorescence with 1.7-fold fluorescence enhancement, when the cells were pretreated with different concentrations of lipopolysaccharide (50-100 μM).

Cell Viability Assay[1]

Cell Line: HeLa cells
Concentration: 10 μM
Incubation Time: 1 hour
Result: Exhibited higher NIR-II fluorescence intensity when pretreated with acetaminophen, resulting in remarkable fluorescence enhancement up to 8.5-fold.
体内研究
(In Vivo)

IR-990 (intravenous injection; 195.31 μg per mouse; once) is a powerful tool for real-time detection of H2O2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (6−8 weeks old, 18−20 g) with acetaminophen-induced liver injury[1]
Dosage: 195.31 μg per mouse
Administration: Intravenous injection; 195.31 μg per mouse; once
Result: Observed NIR-II fluorescence after 20 min for the acetaminophen-treated group, exhibiting the highest fluorescence intensity at 1 h postinjection and a high signal-to-background ratio up to 11.3/1.
分子量

976.53

Formula

C49H47BI2N2O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IR-990 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IR-990IR990IR 990Fluorescent Dyeacceptor-π-acceptorA-π-Adiagnosisdrug-induced liver injuryDILIHeLaHepG2Inhibitorinhibitorinhibit

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产品名称：
IR-990
目录号：
HY-151109
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