2. Immunology/Inflammation NF-κB
  3. IRAK NF-κB
  4. IRAK4-IN-17

IRAK4-IN-17 (Compound 5) 是一种强效 IRAK4 抑制剂，IC50 为 1.3 nM。IRAK4-IN-17 可用于弥漫性大 B 细胞淋巴瘤 (DLBCL) 研究。

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IRAK4-IN-17 Chemical Structure

IRAK4-IN-17 Chemical Structure

CAS No. : 2183503-33-3

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IRAK4-IN-17 相关抗体

Top Publications Citing Use of Products

查看 IRAK 亚型特异性产品:

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IRAK1 IRAK4

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IRAK4-IN-17 (Compound 5) is a potent IRAK4 inhibitor with the IC50 of 1.3 nM[1]. IRAK4-IN-17 can be used in large B-cell lymphoma (DLBCL) research[1].

IC50 & Target[1]

IRAK4

1.3 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HT IC50
40.1 μM
Compound: 5
Cytotoxicity against human HT cells harboring MYD88 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human HT cells harboring MYD88 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 32014679]
OCI-Ly10 IC50
0.7 μM
Compound: 5
Cytotoxicity against human OCILY10 cells harboring MYD88 L265P mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human OCILY10 cells harboring MYD88 L265P mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 32014679]
Ramos IC50
11.4 μM
Compound: 5
Cytotoxicity against human Ramos cells harboring MYD88 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human Ramos cells harboring MYD88 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 32014679]
TMD8 IC50
1.2 μM
Compound: 5
Cytotoxicity against human TMD8 cells harboring MYD88 L265P mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human TMD8 cells harboring MYD88 L265P mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 32014679]
体外研究
(In Vitro)

IRAK4-IN-17 (0.7-40.1 μM; 72 h) selectively suppresses OCI-LY10 and TMD8 cells with MYD88 L265P mutation[1].
IRAK4-IN-17 (0.3-10 μM; 2 h) inhibits the viability of DLBCL cells by targeting IRAK4 signaling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IRAK4-IN-17 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: OCI-LY10, TMD8, Ramos and HT cells
Concentration: 0.7-40.1 μM
Incubation Time: 72 hours
Result: Suppressed OCI-LY10 and TMD8 cells with MYD88 L265P mutation (IC50=0.7 μM and 1.2 μM, respectively), but not Ramos and HT cell lines with WT MYD88 (IC50=11.4 μM and 40.1 μM, respectively).

Western Blot Analysis[1]

Cell Line: OCI-LY10 and TMD8 cells
Concentration: 0.3, 1, 3 and 10 μM
Incubation Time: 2 hours
Result: Inhibited the phosphorylation of IRAK4 and the downstream molecules, IKKβ and NF-κB transcription factor (p65) in OCI-LY10 and TMD8 cells.
分子量

390.39

Formula

C17H20F2N8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IRAK4-IN-17 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRAK4-IN-172183503-33-3IRAKNF-κBInterleukin-1 receptor associated kinaseIL-1R associated kinaseNuclear factor-κBNuclear factor-kappaBOCI-LY10TMD8RamosHTlarge B-cell lymphomaDLBCLMYD88Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-150594
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