2. GPCR/G Protein Apoptosis
  3. Angiotensin Receptor Apoptosis
  4. Irbesartan hydrochloride

Irbesartan hydrochloride  (Synonyms: SR-47436 hydrochloride; BMS-186295 hydrochloride)

目录号: HY-B0202A
产品使用指南

摩尔计算器

Irbesartan (SR-47436) hydrochloride 是一种 Ang II 型 1 (AT1) 受体阻滞剂 (ARB)，具有口服活性。Irbesartan hydrochloride 可放松血管，降低血压，增加血液和氧气供应到心脏。 Irbesartan hydrochloride 可用于高血压、心力衰竭和糖尿病肾病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Irbesartan hydrochloride Chemical Structure

Irbesartan hydrochloride Chemical Structure

CAS No. : 329055-23-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Irbesartan hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Irbesartan hydrochloride:

Irbesartan hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Angiotensin Receptor 亚型特异性产品:

查看所有亚型
AT1 Receptor AT2 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[1].

体外研究
(In Vitro)

Irbesartan hydrochloride (20 μM, 3 h) reduces Th22 cells chemotaxis in vitro[1].
Irbesartan hydrochloride (0 μM, 20 μM, 40 μM and 60 μM) suppresses Th22 cells differentiation in vitro[1].
Irbesartan hydrochloride (20 μM) inhibits Th22 cells related proinflammatory response of TECs in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Irbesartan hydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: CD4+ T cells
Concentration: 0, 20, 40 and 60 μM
Incubation Time: 48 h
Result: Exerted no obvious effect on viability of CD4+T cells.
体内研究
(In Vivo)

Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) reduces Th22 lymphocytosis and serum IL-22 level in Ang II-infused mice[1].
Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) exerts obvious renoprotective effects[1].
Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) relieves systemic inflammation and renal fibrosis in hypertension mice induced by Ang II[1].
Irbesartan hydrochloride (20 μM; for 3 h) can attenuate Th22 cells recruitment and IL-22 secretion, which might be through inhibiting chemotaxis in hypertensive renal injury mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[1]
Dosage: 50 mg/kg
Administration: oral gavage; 50 mg/kg/d; once daily
Result: Displayed low Th22 cells and IL-22, exerted similar inhibitory effect on Th1 cell proportion and displayed decreased IL-22 level in kidney.
Prevented BP elevation markedly and decreased urinary albumin/creatinine ratio, BUN and Scr.
Repressed the expression of IL-1β, IL-6, TNF-α, α-SMA, FN and Col I and diminished the extent of fibrosis.
Animal Model: C57BL/6 mice[1]
Dosage: 20 μM
Administration: 20 μM; for 3 h
Result: Downregulated renal CCL20, CCL22 and CCL27 concentrations.
Clinical Trial
分子量

464.99

Formula

C25H29ClN6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Irbesartan hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Irbesartan329055-23-4SR-47436BMS-186295SR47436SR 47436BMS186295BMS 186295Angiotensin ReceptorApoptosisAng II type 1 (AT1) receptor blocker (ARB)blood vesselsbloodheart failurechemotaxishypertensive renal injuryTh22 cellsdiabetic kidney diseaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Irbesartan hydrochloride
目录号：
HY-B0202A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z